KLHL14 Expression as Predicting Factor of Invasiveness in pitNET
NCT ID: NCT06247709
Last Updated: 2024-02-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
12 participants
OBSERVATIONAL
2023-03-12
2023-12-17
Brief Summary
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This is a multicenter and multidisciplinary study, with the involvement of the Departments of Neurosurgery of the University of Naples Federico II and the Department of Biosciences of the University of Teramo.
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Detailed Description
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Patients refer to neurosurgery for the detection of pituitary adenomas with various presenting symptoms that can be correlated to hormone production or to mass effect produced by the lesion on the optic apparatus or on the oculomotor nerves after invasion of the cavernous sinus. All patients undergo an ophthalmological clinical examination to define the presence of visual alteration and endocrinological assessment to determine eventual hormone hypersecretion. Finally, radiological exams, as magnetic resonance of the sellar region, are performed on patients to evaluate the extension of the pathology, its relationship to the surrounding neurovascular structures and therefore guide neurosurgical resection which is typically performed via an endoscopic endonasal transsphenoidal approach. Except for prolactin secreting pituitary adenomas, for which medical therapy with dopaminergic agonists is a viable approach, surgery with adenoma resection represent the gold standard for treatment.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Cases
All patients undergone surgery for the removal of a pituitary adenoma. Tissue samples of these cases were sent to biochemical essay to measure the expression and localisation of KLHL14.
Immunohistochemical expression in pitNET cells of KLHL14
Lab essay evaluating the expression of KLHL 14
Interventions
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Immunohistochemical expression in pitNET cells of KLHL14
Lab essay evaluating the expression of KLHL 14
Eligibility Criteria
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Inclusion Criteria
* Patients affected by nonfunctioning pituitary adenomas.
Exclusion Criteria
* Pregnant women
* Patient under 18 years
* Patients without capacity of discernment.
18 Years
70 Years
ALL
No
Sponsors
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University of Teramo
OTHER
Federico II University
OTHER
Responsible Party
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Domenico Solari
Associate Professor of Neurosurgery
Principal Investigators
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Barbara Barboni, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Teramo
Locations
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Federico II university
Napoli, , Italy
Countries
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Other Identifiers
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17-1-j
Identifier Type: -
Identifier Source: org_study_id
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