Effects of Dietary Polystyrene Microplastics on Anxiety- and Depression-like Behaviors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-01

Study Completion Date

2024-05-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this clinical trial is to explore the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians. Specifically, the study aims to address two key questions:

1. Can dietary polystyrene microplastics induce alterations in the human gut microbiome?
2. Can dietary polystyrene microplastics exacerbate anxiety- and depression-like behaviors?

Participants will be divided into two groups based on their habitual eating practices: The control group, consisting of resident physicians, will use non-disposable plastic tableware (NDPT) provided by hospital canteens for two months. In contrast, the exposure group, also comprising resident physicians, will use disposable plastic tableware (DPT) made of polystyrene, provided by the same hospital canteens, over the same period.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Investigation Of How PD 0332334 And Metformin Are Eliminated From The Body When They Are Administered At The Same Time

NCT00809536

Generalized Anxiety Disorder

TERMINATED PHASE1

Metformin for Treatment Antipsychotic-induced Metabolic Syndrome in Bipolar Disorder Patients

NCT02644577

Bipolar Disorder

COMPLETED PHASE4

The Effect of Obesity in Dexmedetomidine Metabolic Clearance

NCT02557867

Obesity

UNKNOWN PHASE4

Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder

NCT04124276

Major Depressive Disorder Depression Depressive Disorder

UNKNOWN NA

Effect of Food and Age on the Pharmacokinetics of LY03017

NCT06793995

Alzheimer's Disease Psychosis Parkinson Disease Psychosis Negative Symptoms of Schizophrenia

NOT_YET_RECRUITING PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The mental health and well-being of resident physicians is a critical topic that has gained increasing attention recently. Recent studies have shown a growing prevalence of mental health illnesses worldwide. For medical trainees and resident physicians, high rates of depression, anxiety, suicidal ideation, and burnout have been consistently observed. Moreover, contemporary research suggests that dietary exposure plays a pivotal role in the development of mental illnesses. Disposable plastic tableware, commonly used during resident training programs, could be a contributing factor. However, the specific effects of dietary exposure from such tableware on mental health, particularly through the gut-brain axis, remain largely unexplored. Consequently, investigating the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians is essential.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Depression, Anxiety

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

The exposure group will use disposable plastic tableware (DPT) made of polystyrene, provided by the hospital canteens for two months

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

The control group

The control group, consisting of resident physicians, will use non-disposable plastic tableware (NDPT) provided by hospital canteens for two months.

Group Type NO_INTERVENTION

No interventions assigned to this group

The exposure group

The exposure group, also comprising resident physicians, will use disposable plastic tableware (DPT) made of polystyrene, provided by the same hospital canteens for two months

Group Type EXPERIMENTAL

Dietary polystyrene microplastics from disposable plastic tableware

Intervention Type OTHER

Microplastic release from the daily use of disposable plastic materials (e.g., plastic boxes) when holding hot food or drink.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dietary polystyrene microplastics from disposable plastic tableware

Microplastic release from the daily use of disposable plastic materials (e.g., plastic boxes) when holding hot food or drink.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Volunteer resident physician at the base of Northern Jiangsu Hospital, Yangzhou, China

Exclusion Criteria

* received chemotherapy, radiotherapy, or surgery in the 3 -6 months before sampling
* diagnosed with mental illness
* diagnosed with digestive system diseases

Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes