PET-guided Radiotherapy for Patients With Small Cell Lung Cancer.

NCT ID: NCT06247163

Last Updated: 2024-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-22

Study Completion Date

2029-06-22

Brief Summary

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There is a prospective risk-adapted evaluation of the optimal dose of radiotherapy for definitive radiotherapy of locally advanced small cell lung cancer within the corridor recommended as standard therapy according to the current interdisciplinary S3 guideline of the German Cancer Society/Cancer Aid/AWMF

Detailed Description

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The main objective of this study is to determine whether patients with SCLC who have a metabolically active residual tumor in the fluorodeoxyglucose (FDG) PET/CT scan after two to three cycles of induction chemotherapy have a similarly low local recurrence rate with higher dose. There is a prospective risk-adapted evaluation of the optimal dose of radiotherapy for definitive radiotherapy of locally advanced small cell lung cancer within the corridor recommended as standard therapy according to the current interdisciplinary S3 guideline of the German Cancer Society/Cancer Aid/AWMF. Allocation to PET boost, if confirmed vital tumor rest by PET CT and biopsy.

Conditions

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Small Cell Lung Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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PET based Raditherapy boost

An Interim PET CT will be performed. If there is residual vital tumor, a higher radiation dose will be applied.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Histopathologic confirmation
* Limited disease

Exclusion Criteria

* Other histology than small cell lung cancer
* Further tumor diagnosis
* ECOG 3 or worse
* Extensive disease
* stage IV
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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Maja Guberina

PD Dr. med. (MD) Maja Guberina, specialist in radiation oncology, senior consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital Essen

Essen, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Maja Guberina

Role: CONTACT

020172383121

Facility Contacts

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Maja Guberina

Role: primary

+4920127232321

Other Identifiers

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23-11560-BO

Identifier Type: -

Identifier Source: org_study_id

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