Vitamin D Serum Levels in Monosymptomatic Enuretic and Non Enuretic Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-12

Study Completion Date

2020-09-24

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

We are group of researchers interested in causes and management of nocturnal enuresis, we embarked on this research on 2020 and we reached promising results regarding the role of vitamin D serum level in etiology and management of monosymptomatic enuresis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Vitamin D Versus Desmopressin Versus Combination Therapy in Children With Primary Monosymptomatic Nocturnal Enuresis and Vitamin D Deficiency

NCT07292753

Nocturnal Enuresis Vitamin D Deficiency

COMPLETED NA

Efficacy and Safety of Vitamin D Supplementation Combined With Alarm Therapy in Treating Nocturnal Enuresis

NCT06508333

Enuresis

RECRUITING NA

Efficacy and Safety of Vitamin D in the Treatment of OAB-wet in Children

NCT06201013

Urinary Bladder, Overactive Overactive Bladder Urinary Incontinence, Urge

UNKNOWN NA

Vitamin D Supplementation in Pediatrics. Oral or Parenteral! D2 or D3

NCT06176157

Vitamin D Deficiency

NOT_YET_RECRUITING PHASE4

Different Regimens of Vitamin D in Treatment of Children With Chronic Liver Disease

NCT05717569

Chronic Liver Disease and Cirrhosis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

this research was conducted as a comparative study regarding serum vitamin D levels in monosymptomatic enuretic and non enuretic children, also we compared urine osmolality and nocturnal polyuria in both groups and we found that low vitamin D levels are correlated with low nocturnal urine osmolality and increased incidence of nocturnal polyuria

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Nocturnal Enuresis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Enuretic

Children complaining of monosymptomatic enuresis

serum vitamin D

Intervention Type DIAGNOSTIC_TEST

blood sample for serum vitamin D level Vitamin D serum level was measures using the ELISA technique. The Cal Biotech Vitamin D Kit (Mannheim, Germany) was used, which is a solid phase enzyme linked immunoassay (ELISA), based on the principal of competitive binding. Vitamin D deficiency was defined as serum Vit. D below 20 ng/ml.

urine osmolality

Intervention Type DIAGNOSTIC_TEST

nocturnal urine osmolality: Clear instructions for mothers were to let the child void before sleep and every two hours till 8 am. Short intervals were meant to avoid enuretic episodes during calculation of nocturnal urine volume, and if occurred it mandates the repeat of chart on another day.

Nocturnal urine collected over the night was tested for osmolality, it was measured in mOsm/kg.

Frequency volume chart

Intervention Type OTHER

volume and frequency from time of sleep till 8 am

Non-enuretic

Healthy non enuretic children

serum vitamin D

Intervention Type DIAGNOSTIC_TEST

blood sample for serum vitamin D level Vitamin D serum level was measures using the ELISA technique. The Cal Biotech Vitamin D Kit (Mannheim, Germany) was used, which is a solid phase enzyme linked immunoassay (ELISA), based on the principal of competitive binding. Vitamin D deficiency was defined as serum Vit. D below 20 ng/ml.

urine osmolality

Intervention Type DIAGNOSTIC_TEST

nocturnal urine osmolality: Clear instructions for mothers were to let the child void before sleep and every two hours till 8 am. Short intervals were meant to avoid enuretic episodes during calculation of nocturnal urine volume, and if occurred it mandates the repeat of chart on another day.

Nocturnal urine collected over the night was tested for osmolality, it was measured in mOsm/kg.

Frequency volume chart

Intervention Type OTHER

volume and frequency from time of sleep till 8 am

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

serum vitamin D

blood sample for serum vitamin D level Vitamin D serum level was measures using the ELISA technique. The Cal Biotech Vitamin D Kit (Mannheim, Germany) was used, which is a solid phase enzyme linked immunoassay (ELISA), based on the principal of competitive binding. Vitamin D deficiency was defined as serum Vit. D below 20 ng/ml.

Intervention Type DIAGNOSTIC_TEST

urine osmolality

nocturnal urine osmolality: Clear instructions for mothers were to let the child void before sleep and every two hours till 8 am. Short intervals were meant to avoid enuretic episodes during calculation of nocturnal urine volume, and if occurred it mandates the repeat of chart on another day.

Nocturnal urine collected over the night was tested for osmolality, it was measured in mOsm/kg.

Intervention Type DIAGNOSTIC_TEST

Frequency volume chart

volume and frequency from time of sleep till 8 am

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with PMNE.
* which was defined as bedwetting frequency of 3 or more nights per week for at least 2 weeks of observation.
* Didn't receive any previous treatment for enuresis.

Exclusion Criteria

* Patients with non-monosymptomatic enuresis (associated with storage and/or voiding symptoms). -Patients with anatomical abnormalities (Meatal stenosis, Hypospadias, Epispadias, etc.).
* Patients with neurological diseases.
* Patients with Renal impairment.
* Patient with previous pelvic, urological or brain and spinal cord surgery.
* Patients with chronic constipation and irritable bowel habits.
* Patients with active urinary tract infection.
* Patients who are on vitamin D supplements.

Minimum Eligible Age

5 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No