Relationship Between Serum Vitamin D Levels and Postherpetic Neuralgia.

NCT ID: NCT06232486

Last Updated: 2024-01-30

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 144 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-12-01
• Study Completion Date: 2026-12-31

Brief Summary

1. The correlations of serum vitamin D level, serum calcium level and osteoporosis degree with disease severity, treatment response, incidence of Post-Herpes zoster(PHN) and disease prognosis in Herpes zoster(HZ) patients were studied.

2. To investigate the role of inflammation-related factors and immune-related factors in the occurrence and development of HZ mediated by low vitamin D level.

Detailed Description

Herpes zoster is a neuropathic disease which induce by the varicella-herpes virus reactivation.and postherpetic neuralgia (PHN) is the most common complication. Currently,the mechanism of herpes zoster still unclearly even though there had much study about it .Vitamin D is an essential vitamin for human body, which has the function of maintaining calcium and phosphorus homeostasis and immune regulation. Vitamin D is a natural antiviral substance, and vitamin D deficiency can affect the body's antiviral ability, thereby promoting varicella-zoster virus(VZV) reactivation, and may promote the development of PHN through continuous neuroinflammation. Therefore, vitamin D level may be related to the occurrence and progression of HZ. this study intends to use an observational cohort study design to investigate the correlation of serum vitamin D level and osteoporosis degree with the severity of the herpes zoster disease, Although we plan to further explore the role of inflammatory state in this process.

Conditions

Postherpetic Neuralgia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Herpes zoster patients

The patient was diagnosed with herpetic neuralgia and the course of disease was ≤3 months;

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Age ≥18 years.
• The patient was diagnosed with herpetic neuralgia and the course of disease was ≤3 months.
• Can cooperate with the completion of inquiry and scale evaluation.

Exclusion Criteria

• Severe spinal disease (fracture, malignancy, acute or chronic infection) confirmed by previous spinal surgery or imaging.
• Previous history of head trauma.
• Have autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, leucothrombocytopenia).
• Suffering from mental disorders, intellectual disability, epilepsy and other diseases.
• A history of substance abuse, drug abuse or alcohol abuse.
• Pregnant or breastfeeding women.
• And recent participation in other clinical studies.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Feng Gao

OTHER

Sponsor Role: lead

Responsible Party

Feng Gao

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Tongji Hospital

Wuhan, Hubei, China

Countries

China

Other Identifiers

TJ-IRB20231251

Identifier Type: -

Identifier Source: org_study_id