Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate.
NCT ID: NCT06231849
Last Updated: 2024-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
52 participants
OBSERVATIONAL
2024-02-29
2026-04-30
Brief Summary
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Detailed Description
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The investigator will discuss this role of gut microbiome in Assuit university hospital to see how the pathogenesis can be altered of drug addiction.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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normal subjects without opioid intoxications.
1\. Individuals of male gender aged between 20 to 35 years old
No interventions assigned to this group
individuals with opioid use disorders.
Individuals of male gender aged between 20 to 35 years old with opioid use disorders.
stool analysis
stool analysis to determine number of gut microbiota in subjects with opioid use and its effect on its intoxication.
Interventions
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stool analysis
stool analysis to determine number of gut microbiota in subjects with opioid use and its effect on its intoxication.
Eligibility Criteria
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Inclusion Criteria
2. Must be encountering withdrawal symptoms for the first time.
Exclusion Criteria
2. Gastrointestinal diseases.
20 Years
35 Years
MALE
No
Sponsors
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Assiut University
OTHER
Responsible Party
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ahmed mohammed abdelrahim
Resident doctor
Principal Investigators
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Central Contacts
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References
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Acharya C, Betrapally NS, Gillevet PM, Sterling RK, Akbarali H, White MB, Ganapathy D, Fagan A, Sikaroodi M, Bajaj JS. Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis. Aliment Pharmacol Ther. 2017 Jan;45(2):319-331. doi: 10.1111/apt.13858. Epub 2016 Nov 20.
Akbarali HI, Dewey WL. The gut-brain interaction in opioid tolerance. Curr Opin Pharmacol. 2017 Dec;37:126-130. doi: 10.1016/j.coph.2017.10.012. Epub 2017 Nov 13.
Berridge KC. From prediction error to incentive salience: mesolimbic computation of reward motivation. Eur J Neurosci. 2012 Apr;35(7):1124-43. doi: 10.1111/j.1460-9568.2012.07990.x.
Other Identifiers
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gut microbiota in opioid use
Identifier Type: -
Identifier Source: org_study_id
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