Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-01

Study Completion Date

2025-11-21

Brief Summary

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This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

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Detailed Description

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This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.

Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Conditions

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Abdominal Surgery Endotracheal Intubation Surgical Incision Electroencephalogram

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Endotracheal intubation

Inserting endotracheal tube into the trachea

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 1\) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
* 2\) Patients requiring invasive blood pressure monitoring during surgery

Exclusion Criteria

* 1\) Patients transferred to the intensive care unit after surgery
* 2\) Surgery duration of less than one hour
* 3\) Patients with neurological underlying conditions
* 4\) Patients on chronic use of psychotropic medications and opioid drugs
* 5\) Emergency surgery

Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No