Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
50 participants
OBSERVATIONAL
2024-02-06
2025-02-28
Brief Summary
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Ultrasound is a non-invasive imaging technique that uses high-frequency sound waves to produce images of internal structures. Conventional ultrasound in B-mode can only provide details about the tumor's number, size, and location.
Elastography uses ultrasound imaging techniques to examine the stiffness of a tissue. Using the Aixplorer system many recently published papers suggested that ShearWave Elasticity (SWE) imaging, enables the differentiation of low- from high-grade breast tumors by assessing the elasticity of the tissue.
Investigators intend to evaluate the stiffness of bladder tumors with ultrasound elastography in comparison with cystometry parameters and tumoral grade.
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Detailed Description
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Ultrasound is a non-invasive imaging technique that uses high-frequency sound waves to produce images of internal structures. Conventional ultrasound in B-mode can only provide details about the tumor's number, size, and location.
Elastography uses ultrasound imaging techniques to examine the stiffness of a tissue. Using the Aixplorer system many recently published papers suggested that ShearWave Elasticity (SWE) imaging, enables the differentiation of low- from high-grade breast tumors by assessing the elasticity of the tissue. Many studies have shown a significant correlation between ultrasound elastography of the bladder wall with measurements of the detrusor pressure. Only one study, conducted by Huang et al., have assessed its application in the evaluation of bladder cancer with an intraluminal transducer. A significant difference between elasticity of low grade and high grade bladder tumors was found. However, no data on the impact of the intravesical volume over the tumoral elasticity is available.
The objective of this project is to evaluate the correlation between the ultrasound Elastography of urothelial bladder tumors with their tumoral grade before transurethral resection of the bladder.
Knowing that ultrasound Elastography is impacted by the pressure applied to a tissue, investigators intend to measure the tumoral elasticity - with an abdominal ultrasound transducer - during bladder filling with a monitoring of the intravesical pressure.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Experimental : Urothelial bladder tumour
Patient with an indication of transurethral resection of the bladder. Following the Urology consultation, the patient will be called for a trans-urethral bladder resection within 1 month. The patient will be admitted to the Urology Department of the Tours University Hospital the previous day.
urethral bladder resection
urethral bladder resection. Per-operative bladder ultrasound elastography and simultaneous cystometry
Interventions
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urethral bladder resection
urethral bladder resection. Per-operative bladder ultrasound elastography and simultaneous cystometry
Eligibility Criteria
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Inclusion Criteria
* Bladder tumour visualised on abdominal ultrasound or estimated to be more than 2 cm in diameter by fibroscopy or CT scan
* Primary resection
Exclusion Criteria
* Bladder catheterisation,
* Previous bladder or prostate surgery,
* Previous intravesical instillation (BCG / Ametycine)
* Previous pelvic radiotherapy,
* Person having objected to data processing.
18 Years
ALL
No
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Franck BRUYERE
Role: PRINCIPAL_INVESTIGATOR
University Hospital
Locations
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University hospital
Tours, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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DR230158 - SONURO
Identifier Type: -
Identifier Source: org_study_id
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