Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity
NCT ID: NCT06214468
Last Updated: 2024-01-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
PHASE1
40 participants
INTERVENTIONAL
2024-01-15
2025-04-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
It is believed that acetaminophen promotes the productions of chemicals in the body that could be toxic.
In this study, measurements of these chemicals in urine after ingestion of 1 tablet of acetaminophen and compare these measurements to when acetaminophen is taken at the same time as a dietary supplement. This study will also explore whether these products are more abundant when blood is placed under conditions that mimic space. Therefore, this study will collect blood from a few volunteers who took acetaminophen, and acetaminophen with the dietary supplement.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione
NCT00228644
Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
NCT01575847
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
NCT04005053
A Study of N-Acetyl Cysteine in Children With Autism
NCT00627705
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
NCT02922673
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The study will measure these materials in urine after ingestion of 1 gram of acetaminophen and compare these measurements to when the same amount of acetaminophen is taken at the same time as NR. It will also evaluate whether these toxins are more abundant when blood is placed under conditions resembling space. Therefore, blood collection from a few volunteers who take acetaminophen, and acetaminophen with NR. Ultimately, this work will establish whether NR could reduce the generation of specific endotoxins.
For this study, male and female volunteers are needed to donate urine for testing the effect of 1000mg dose of Tylenol® and one 1000mg dose of Tylenol® with one 250mg dose of Nicotinamide Riboside on the abundance of uremic toxins in urine and in blood. Volunteers are also needed to donate blood.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
CROSSOVER
Tubes will be provided for the collection of the urine and zip lock bags will be provided to place the tubes in after samples have been collected. All samples should be stored in the freezer until completion of the samples at which time they should be brought to the USA Mitchell Cancer Institute. Some volunteers will participate in 4 total blood draws collected on the first day at the time of the consent then again 6 hours after taking NR and Acetaminophen. Blood samples will be taken again during the second collection period.
DIAGNOSTIC
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Tylenol and Nicotinamide Riboside
Acetaminophen and Nicotinamide Riboside
Collection of urine at different time intervals following ingestion of Tylenol plus Nicotinamide Riboside
Acetaminophen
Collection of urine at different time intervals following ingestion of Tylenol only
Tylenol Only
Acetaminophen
Collection of urine at different time intervals following ingestion of Tylenol only
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Acetaminophen and Nicotinamide Riboside
Collection of urine at different time intervals following ingestion of Tylenol plus Nicotinamide Riboside
Acetaminophen
Collection of urine at different time intervals following ingestion of Tylenol only
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Aeronautics and Space Administration (NASA)
FED
University of Nevada, Las Vegas
OTHER
University of Alabama at Birmingham
OTHER
Rutgers University
OTHER
University of South Alabama
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Marie Migaud
Professor of Pharmacology
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
marie migaud, PHD
Role: PRINCIPAL_INVESTIGATOR
University of South Alabama
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of South Alabama
Mobile, Alabama, United States
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
23-067/2026659-2
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.