Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-20

Study Completion Date

2024-02-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this observational study is to learn about in effects of trace element metabolism, tricarboxylic acid cycle enzyme activities and thiol/disulfide balance in patients who underwent cesarean section under spinal anesthesia. The main question\[s\] it aims to answer are:

• What is the effect of trace element metabolism, tricarboxylic acid cycle enzyme activities and thiol/disulfide balance in patients undergoing cesarean section under regional anesthesia? A 10 ml blood sample will be taken from the participants to analyze the biochemical parameters mentioned before and after the operation. Pre- and post-operative values will be compared.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Low Dose Spinal Anesthesia in Cesarean Surgery

NCT02563795

Maternal Hypotension Anesthesia

COMPLETED

Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis

NCT05494268

COMPLETED

Effect of Delivery Time on Umbilical Cord Blood Gas Parameters in Cesarean Sections Under General and Spinal Anesthesia

NCT07321041

Umbilical Cord Blood Cesarean Section Surgery General Anesthesia +2 more

NOT_YET_RECRUITING

The Effect of Combined Spinal Epidural Anaesthesia on QTc Interval Undergoing Cesarean Section

NCT06018805

Analgesia

RECRUITING NA

The Effect of Injection Rate of Local Anesthetic in Caesarean Section

NCT05091294

Anesthesia, Spinal Anesthesia, Obstetrical

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Although the World Health Organization recommends the cesarean birth rate as 10-15%, the cesarean birth rate in Turkey is 57.3% according to 2020 data, ranking first in the world. This rate is around 30% for primary cesarean delivery. Although there are various methods of anesthesia for cesarean birth, spinal block is a regional anesthesia method frequently used in elective cesarean births because it is easy to apply, has a rapid onset of effect and provides a good sensory block. With this anesthesia method, local anesthetic solution is administered to the subarachnoid space to create sensory and motor block within the surgical area.

Although trace elements (Zinc (Zn), Iron (Fe), Copper (Cu)) constitute a small part of the human body, they play a very important role in maintaining normal metabolic function. Deficiency or excess of these elements causes dysfunction of the relevant enzymes (such as alcohol dehydrogenase, alkaline phosphatase, lactate dehydrogenase, carboxypeptidase, carbonic anhydrase, superoxide dismutase (SOD), DNA and RNA polymerase) and thus various clinical findings (postpartum hemorrhage, fetal growth restriction). FGR), fetal malformations, premature birth, preeclampsia).

In recent years, it has been revealed that thiol-disulfide homeostasis may be an important biomarker of oxidative stress. Thiol is a compound containing sulfhydryl group (-SH) that plays an important role in preventing oxidative stress in cells. Thiols are not only a redox buffer in the body but also an essential element of the antioxidant defense system. Abnormal thiol-disulfide balance levels are associated with oxidative stress. There is a balance between oxidative stress and antioxidant defense mechanisms. The changes in this balance depending on many factors are frequently investigated in patients undergoing surgery.

This study aimed to contribute to the literature by investigating the effects of trace element metabolism, tricarboxylic acid cycle enzyme activities and thiol/disulfide balance in patients who underwent cesarean section under spinal anesthesia.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cesarean Section Spinal Anesthesia Thiol Groups

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients who will undergo planned cesarean section between the ages of 18 and 40
2. ASA 1-2 Patients

Exclusion Criteria

1. Patients who refuse to participate in the study
2. Patients over 40 years of age
3. ASA 3-4 Patients
4. Patients who underwent emergency cesarean section
5. Those with known liver and kidney diseases, patients diagnosed with Diabetes Mellitus
6. Pregnant women diagnosed with an abnormal baby
7. Patients diagnosed with preeclampsia
8. Patients with body mass index ≥ 30
9. Patients who do not accept spinal anesthesia or have contraindications to the application -

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No