A Clinical Trial to Evaluate the Food Effect on Pharmacokinetic Profiles and Safety of CKD-379

NCT ID: NCT06204107

Last Updated: 2024-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-21

Study Completion Date

2023-12-06

Brief Summary

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This is a randomized, open-label, single dose, crossover, phase Ⅰ trial to evaluate the food effect on pharmacokinetic profiles and safety of CKD-379 in healthy volunteers

Detailed Description

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Participants were randomly assigned in a 1:1 ratio. The patients are prescribed oral administration of the appropriate IP(2 tablets in single dose: actual medication)

Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1

* Phase 1: CKD-379 Test drug
* Phase 2: CKD-379 Reference drug

Group Type EXPERIMENTAL

CKD-379(Empagliflozin+sitagliptin+metformin) Test drug

Intervention Type DRUG

oral, once

CKD-379(Empagliflozin+sitagliptin+metformin) Reference drug

Intervention Type DRUG

oral, once

Group 2

* Phase 1: CKD-379 Reference drug
* Phase 2: CKD-379 Test drug

Group Type EXPERIMENTAL

CKD-379(Empagliflozin+sitagliptin+metformin) Test drug

Intervention Type DRUG

oral, once

CKD-379(Empagliflozin+sitagliptin+metformin) Reference drug

Intervention Type DRUG

oral, once

Interventions

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CKD-379(Empagliflozin+sitagliptin+metformin) Test drug

oral, once

Intervention Type DRUG

CKD-379(Empagliflozin+sitagliptin+metformin) Reference drug

oral, once

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy adults aged 19 to 54 years
* BMI measurement result is 18.0 kg/m2 to 30 kg/m2
* Written informed consent

Exclusion Criteria

* History of clinically significant liver, kidney, blood, digestive, respiratory, endocrine, cardiovascular, neurological, mental, or immune system disorders
* AST or ALT or total bilirubin \> 1.5 times the upper limit of normal range
* History of regular alcohol consumption \> 21 units/week within 6 months at the time of screening
* Participated in a clinical trial within 6 months prior to 1st IP dosing
Minimum Eligible Age

19 Years

Maximum Eligible Age

54 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jaeyong Jeong

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Bundang Hospital

Locations

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Seoul National University Bundang Hospital

Seongnam, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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A125_05FDI2310

Identifier Type: -

Identifier Source: org_study_id

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