Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study
NCT ID: NCT06194058
Last Updated: 2024-06-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1150 participants
OBSERVATIONAL
2023-11-15
2025-05-15
Brief Summary
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The goal of this prospective, observational, multicenter, anesthetic study is to describe the clinical practice of French anesthesiologists regarding the prevention of severe hemodynamic disorders during rapid sequence anesthetic induction in adult patients.
The primary outcome measure is the occurrence of a major haemodynamic disorder defined by a MBP ≤ 50 mmHg (or ≤ 40% of the reference value) and/or ≥ 110 mmHg and/or the occurrence of sustained arrhythmia not present at induction and/or cardiac arrest within the first 10 minutes after induction of anesthesia.
The clinical practices of pre-oxygenation, induction and intubation of French anesthesiologists and compliance with the formalized expert recommendations of 2017 and 2018 will also be studied secondarily. The elements for the prevention of gastric fluid inhalation, the organization and equipment used, the anesthetic and non-anesthetic drugs used, the clinical and paraclinical neurological and cardio-respiratory parameters and the nature of the complications following anaesthetic induction will be collected up to the 10th post-induction minute.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Interventions
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rapid sequence anesthetic induction
Rapid sequence induction and intubation (or crash induction) is a process for inducing general anesthesia when the patient is at a high risk of pulmonary aspiration. It aims at minimizing the time between giving the induction drugs and securing the tube, during which period the patient's airway is essentially unprotected.
Eligibility Criteria
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Inclusion Criteria
* Procedure requiring general anesthesia with oro or nasotracheal intubation
* Anesthetic management with indication of rapid sequence induction
* No objection after oral and written information to the patient
Exclusion Criteria
* Impossible intubation planned
* Preoperative respiratory distress (SpO2 \< 90% in ambient air)
* Preoperative shock (MBP≤ 65 mmHg or vasopressive amines)
* Preoperative coma defined by a Glasgow score ≤ 12/15
* Patient in cardiopulmonary arrest
* Patients under guardianship or curatorship
18 Years
ALL
No
Sponsors
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Société Française d'Anesthésie et de Réanimation
OTHER
Nantes University Hospital
OTHER
Responsible Party
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Principal Investigators
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Nicolas Grillot, MD
Role: STUDY_DIRECTOR
Nantes University Hospital
Locations
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Clinique Victor Pauchet
Amiens, , France
Hospital
Arcachon, , France
Hospital
Armentières, , France
Hôpital Privé Arras les Bonnettes
Arras, , France
University Hospital
Brest, , France
University Hospital
Caen, , France
Centre Hospitalier Intercommunal
Castres, , France
University Hospital
Clermont-Ferrand, , France
CHD Vendée
La Roche-sur-Yon, , France
University Hospital
Lille, , France
Hospital
Lorient, , France
Centre Léon Bérard
Lyon, , France
Clinique de la Sauvegarde
Lyon, , France
Saint Joseph Saint Luc Hospital
Lyon, , France
University Hopital - Edouard Herriot
Lyon, , France
University Hospital - Sud
Lyon, , France
Hospital
Mont-de-Marsan, , France
Hospital
Montargis, , France
University Hospital
Nantes, , France
University Hospital - Pasteur
Nice, , France
Bichat Hospital - APHP
Paris, , France
Hopital Lariboisiere - APHP
Paris, , France
Hopital Pitié Salpetriere - APHP
Paris, , France
Hopital Saint Louis, Lariboisiere, Fernand Widal - APHP
Paris, , France
Hôpital Tenon - APHP
Paris, , France
University Hospital
Poitiers, , France
Clinique de la Sagesse
Rennes, , France
Hospital
Rodez, , France
Yves Le Foll Hospital
Saint-Brieuc, , France
University Hospital La Réunion - Site Nord
Saint-Denis, , France
University Hospital La Réunion - site Ouest
Saint-Paul, , France
Groupe Hospitalier Seclin Carvin
Seclin, , France
Centre Clinical - Angoulême
Soyaux, , France
Hospital
St-Malo, , France
Clinique Rhéna
Strasbourg, , France
University Hospital - Hautepierre
Strasbourg, , France
Hôpitaux du Leman
Thonon-les-Bains, , France
Centre hospitalier intercommunal
Toulon, , France
University Hospital - Rangueil
Toulouse, , France
Hospital
Valenciennes, , France
Institut Gustave Roussy
Villejuif, , France
Clinique de Villeneuve Saint Georges
Villeneuve-Saint-Georges, , France
Countries
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Central Contacts
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Facility Contacts
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Pierre Huette
Role: primary
Matthias Garrot
Role: primary
Anais Caillard
Role: primary
Mathieu Oudot
Role: primary
Victor Lestrade
Role: primary
Grégoire Wallon
Role: primary
Olivier Desebbe
Role: primary
Hugo Ingles
Role: primary
Gauthier Hamon
Role: primary
Gianluca Caragliano
Role: primary
Nadège Erb
Role: primary
Fanny Cointre
Role: primary
Virginie Trehel-Tursis
Role: primary
Other Identifiers
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AR_2023_001
Identifier Type: -
Identifier Source: org_study_id
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