Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease

NCT ID: NCT06190158

Last Updated: 2025-04-09

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 125 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-05-15
• Study Completion Date: 2029-07-31

Brief Summary

The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.

Detailed Description

Diabetes is the leading cause of chronic kidney disease (CKD). When combined, diabetes with CKD exponentially increases risk for cardiovascular disease (CVD) and death. Preventing or delaying CKD in diabetes would substantially decrease these adverse outcomes, save billions in healthcare expenditures, and improve quality of life for those at high-risk for dialysis-dependent kidney failure.

Emerging evidence strongly suggests that primary aldosteronism (PA) pathophysiology is a causative mechanism for the development and progression of CKD in diabetes. PA pathophysiology is characterized by relatively non-suppressible and renin-independent aldosterone production that causes excessive activation of the mineralocorticoid receptor (MR). This maladaptive activation of the MR induces inflammation and fibrosis that contributes to hypertension (HTN), CKD, cardiovascular disease, and death.

PA has traditionally been considered to be a rare and categorical disorder. However, it has been shown that PA pathophysiology exists across a broad continuum of severity, from mild (or subclinical) to overt (or severe); in this regard, PA is better considered to be a pathophysiologic syndrome. The origins of PA pathophysiology can be observed in normotensive and pre-hypertensive people, which consequently increases the risk for developing HTN, developing CKD and progression of CKD to end-stage kidney disease, structural heart disease, and adverse CVD outcomes. Thus, early identification of PA pathophysiology is of critical importance since widely available targeted therapies (such as MR antagonists) can mitigate these adverse outcomes.

The prevalence of PA pathophysiology is high and almost entirely unrecognized. It can be detected in 10-25% of the general population. In high-risk populations, such as those with resistant hypertension and/or hypertension with hypokalemia, the prevalence of PA exceeds 25%. However, despite this alarming prevalence, the rates of testing for PA, or empiric MR antagonist use, in these high-risk populations is abysmal and rarely exceeds 2%. The scope of this problem is magnified by the fact that randomized clinical trials have established the exceptional efficacy of MR antagonists. Landmark trials have established the efficacy of MR antagonist therapy for treating PA, controlling resistant HTN, reducing adverse outcomes in heart failure, reducing albuminuria, and most germane to this proposal, for lowering the risk of CKD progression and incident end-stage kidney disease in patients with diabetes and incident CVD outcomes despite the use of ACEi/ARBs.

GAPS IN CURRENT UNDERSTANDING: What is the mechanism by which MR antagonists impart reno-protective benefits in patients with type 2 diabetes? Ground-breaking results of clinical trials led to the FDA approval of the MR antagonist finerenone and changes to clinical practice guidelines to employ MR antagonists to prevent CKD progression in type 2 diabetes; however, the role of PA pathophysiology was not directly investigated. The investigators hypothesize that there is a prevalent, progressive, and unrecognized, spectrum of PA pathophysiology and MR activation in people with diabetes who have, or are vulnerable to developing, CKD.

The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.

Conditions

Type 2 Diabetes; Chronic Kidney Diseases

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

type 2 diabetes at risk for chronic kidney disease

type 2 diabetes at risk for chronic kidney disease

Group Type: EXPERIMENTAL

Oral sodium suppression test

Intervention Type: DIAGNOSTIC_TEST

Oral sodium suppression test (\~2 grams of supplemental sodium for 3 days)

Saline suppression test

Intervention Type: DIAGNOSTIC_TEST

Saline suppression test (2 liters of saline)

Captopril suppression test

Intervention Type: DIAGNOSTIC_TEST

Captopril suppression test (50mg of captopril)

Dexamethasone suppression test

Intervention Type: DIAGNOSTIC_TEST

1mg of dexamethasone

Cosyntropin stimulation test

Intervention Type: DIAGNOSTIC_TEST

250mcg of cosyntropin

Interventions

Oral sodium suppression test

Oral sodium suppression test (\~2 grams of supplemental sodium for 3 days)

Intervention Type: DIAGNOSTIC_TEST

Saline suppression test

Saline suppression test (2 liters of saline)

Intervention Type: DIAGNOSTIC_TEST

Captopril suppression test

Captopril suppression test (50mg of captopril)

Intervention Type: DIAGNOSTIC_TEST

Dexamethasone suppression test

1mg of dexamethasone

Intervention Type: DIAGNOSTIC_TEST

Cosyntropin stimulation test

250mcg of cosyntropin

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

1. Age 18-80 years

2. Known diagnosis of type 2 diabetes; or unknown/unclear diagnosis of type 2 diabetes but hemoglobin A1c 5.7-6.4% on screening while on treatment with metformin or SGLT2 inhibitor or GLP1RA class of medications; or unknown/unclear diagnosis of type 2 diabetes but hemoglobin A1c 6.5-8.9% on screening.

• Moderate albuminuria (30-300 mg/g)
• Diagnosis of hypertension or active treatment with anti-hypertensive medications
• BMI ≥ 30 kg/m2 ii. At-risk for CKD progression: eGFR 45-60 mL/min/1.73m2

Exclusion Criteria

• Type 1 or Type 3 diabetes
• Hemoglobin A1c ≥ 9%
• Inability to safely participate in fasting study visits (determination at the discretion of PI and MD study staff based on cumulative assessment of safety factors)
• Average blood pressure at screening visit of >150 mmHg systolic or >100 mmHg diastolic
• Screening average systolic blood pressure less than 105 mmHg without the use of an ACE inhibitor or angiotensin receptor blocker
• Inability to safely withdraw ACE inhibitor or angiotensin receptor blocker medication in lieu of alternative medication for a few weeks (determination at the discretion of PI and MD study staff based on cumulative assessment of factors)
• Known history of stroke, symptomatic coronary artery disease, myocardial infarction, heart failure, cerebral or aortic aneurysm.
• Known cardiac murmur suggestive of aortic stenosis or mitral regurgitation, or detected newly on screening physical examination
• Active cancer that is being treated with chemotherapeutic agents
• Pregnancy
• Breast feeding
• Daily use of prescribed opioid medications
• Illicit drug use (cocaine, heroin, methamphetamine)
• Daily use of oral glucocorticoids
• Electrocardiogram that shows evidence of prior myocardial infarction, atrial arrhythmia, left or right bundle branch blocks.
• Hematocrit < 32% or Hemoglobin < 10 g/dl (women) or Hemoglobin < 11 g/dl (men) on the day of screening
• eGFR <45 mL/min/1.73m2 on the day of screening
• Known allergy to ACE inhibitors, cosyntropin
• Active use of a mineralocorticoid receptor antagonist

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Brigham and Women's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Anand Vaidya

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Anand Vaidya, MD

Role: CONTACT

anandvaidya@bwh.harvard.edu

16177325666

Facility Contacts

Anand Vaidya, MD

Role: primary

anandvaidya@bwh.harvard.edu

6177325666

Other Identifiers

2023p003466

Identifier Type: -

Identifier Source: org_study_id