Interference by Activated Protein C Resistance in the Determination of Protein S Activity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

9470 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-07-01

Study Completion Date

2023-12-31

Brief Summary

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Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Detailed Description

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Conditions

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Resistance to Activated Protein C in the Determination of Protein S Activity

Keywords

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protein C protein S activated protein C

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient of legal age (≥ 18 years)
* Patient for whom a sample has been sent to the HUS Hematology Laboratory for measurement of protein S activity between 28/12/2009 and 29/12/2020
* Patient who does not object to the reuse of his/her medical data for scientific research purposes.

Exclusion Criteria

* Minor patient
* Patient with incomplete data

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Laboratoire d'Hématologie - CHU de Strasbourg - France

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Agathe HERB, MD, PhD

Role: CONTACT

Phone: 33 3 88 12 75 53

Email: [email protected]

Facility Contacts

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Agathe HERB, PharmD

Role: primary

Other Identifiers

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8674

Identifier Type: -

Identifier Source: org_study_id