Field Evaluations of Innovative Tools for Vector-borne Disease Control in Conflict-affected Communities
NCT ID: NCT06179732
Last Updated: 2024-04-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
2400 participants
INTERVENTIONAL
2023-06-05
2023-12-31
Brief Summary
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By conducting the research in challenging camp settings in the north of Nigeria, the MENTOR Initiative aims to determine whether Mesh can be effective in harsh camp conditions where communities are living in conflict area temporary shelters.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Control
1. Information and Education Campaigns (IEC) campaigns will formally encourage breeding site management through; good practice household-level water storage (covering and cleaning of water storage containers) and waste management (removal of potential breeding sites in and around the home).
2. Epidemiological surveillance: test and treat malaria cases in children 6 - 10 years of age
No interventions assigned to this group
Mesh
1. Information and Education Campaigns (IEC) campaigns will formally encourage breeding site management through; good practice household-level water storage (covering and cleaning of water storage containers) and waste management (removal of potential breeding sites in and around the home).
2. Epidemiological surveillance: test and treat malaria cases in children 6 - 10 years of age
3. Mesh product distributed to households
Mesh - spatial repellent impregnated with transfluthrin (2500mg)
Mesh is one of the first spatial repellent tools to provide long-lasting protection to users, with predicted efficacy of 6-months. The active ingredient of Mesh is transfluthrin, a fast-acting volatile pyrethroid with low persistency, which can act either by killing or via sublethal toxicity that causes deviation (repellency) in host attraction, reducing host-contact and risk of infectious bites. The chemical passively releases into the air and interacts with vector odour receptors causing irritation. The design of Mesh is simple with a transfluthrin-infused sheet protected by plastic mesh and encased in a plastic frame.
Mesh will be distributed to the intervention arm only.
Information and Education Campaigns (IEC)
IEC campaigns will formally encourage breeding site management through; good practice household-level water storage (covering and cleaning of water storage containers) and waste management (removal of potential breeding sites in and around the home) using leaflets and word of mouth. IEC will be conducted in both arms.
test and treat malaria cases
All children in the cohort (both arms) will be tested by rapid diagnostic testing (RDT) monthly. If any children test positive, they will be treated with a course of 3-day artemisinin combination therapy (ACT) according to standard protocol and local guidelines. All children in the cohort will receive ACT to provide clearance of any malaria parasites during the baseline of the study.
Interventions
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Mesh - spatial repellent impregnated with transfluthrin (2500mg)
Mesh is one of the first spatial repellent tools to provide long-lasting protection to users, with predicted efficacy of 6-months. The active ingredient of Mesh is transfluthrin, a fast-acting volatile pyrethroid with low persistency, which can act either by killing or via sublethal toxicity that causes deviation (repellency) in host attraction, reducing host-contact and risk of infectious bites. The chemical passively releases into the air and interacts with vector odour receptors causing irritation. The design of Mesh is simple with a transfluthrin-infused sheet protected by plastic mesh and encased in a plastic frame.
Mesh will be distributed to the intervention arm only.
Information and Education Campaigns (IEC)
IEC campaigns will formally encourage breeding site management through; good practice household-level water storage (covering and cleaning of water storage containers) and waste management (removal of potential breeding sites in and around the home) using leaflets and word of mouth. IEC will be conducted in both arms.
test and treat malaria cases
All children in the cohort (both arms) will be tested by rapid diagnostic testing (RDT) monthly. If any children test positive, they will be treated with a course of 3-day artemisinin combination therapy (ACT) according to standard protocol and local guidelines. All children in the cohort will receive ACT to provide clearance of any malaria parasites during the baseline of the study.
Eligibility Criteria
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Inclusion Criteria
* Shelters with an adult/head of the household
Exclusion Criteria
6 Years
10 Years
ALL
Yes
Sponsors
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Liverpool School of Tropical Medicine
OTHER
University of Maiduguri
OTHER
US government
UNKNOWN
SCJohnson
UNKNOWN
The Mentor Initiative
OTHER
Responsible Party
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Principal Investigators
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Richard Allan
Role: PRINCIPAL_INVESTIGATOR
The Mentor Initiative
Locations
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Sara Estecha Querol
Haywards Heath, West Sussex, United Kingdom
Countries
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Other Identifiers
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USDA01YEM - Nigeria
Identifier Type: -
Identifier Source: org_study_id
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