A Clinical Study of the V116 Vaccine for Children and Teenagers (V116-013)

NCT ID: NCT06177912

Last Updated: 2025-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

882 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-18

Study Completion Date

2025-02-26

Brief Summary

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The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of V116 compared to PPSV23 in children 2 through 17 years of age. Researchers want to learn if V116 is as good as, or is better than the PPSV23 vaccine in terms of the antibody immune response. V116 and PPSV23 will be studied in children and teenagers who have a higher risk of getting invasive pneumococcal disease (IPD).

Detailed Description

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Conditions

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Pneumococcal Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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V116

Participants will receive a single 0.5 mL intramuscular (IM) injection of V116 on Day 1

Group Type EXPERIMENTAL

V116

Intervention Type BIOLOGICAL

Pneumococcal 21-valent conjugate vaccine with 4 μg of each of the following pneumococcal polysaccharides (PnPs) antigen: 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B in each 0.5 mL sterile solution

PPSV23

Participants will receive a single 0.5 mL IM dose of PPSV23 on Day 1.

Group Type ACTIVE_COMPARATOR

PPSV23

Intervention Type BIOLOGICAL

Pneumococcal 23-valent conjugate vaccine with 25 μg of each of the following PnPs antigen: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F in each 0.5 mL sterile solution

Interventions

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V116

Pneumococcal 21-valent conjugate vaccine with 4 μg of each of the following pneumococcal polysaccharides (PnPs) antigen: 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B in each 0.5 mL sterile solution

Intervention Type BIOLOGICAL

PPSV23

Pneumococcal 23-valent conjugate vaccine with 25 μg of each of the following PnPs antigen: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F in each 0.5 mL sterile solution

Intervention Type BIOLOGICAL

Other Intervention Names

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Pneumococcal 21-valent Conjugate Vaccine PNEUMOVAX™23

Eligibility Criteria

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Inclusion Criteria

* Has a diagnosis and stable medical management (for at least 3 months) of one of the following risk conditions for pneumococcal disease: Diabetes mellitus, chronic compensated liver disease, chronic lung disease, chronic heart disease, or chronic kidney disease.
* Has completed pneumococcal conjugate vaccine regimen (PCV7, PCV10, or PCV13) at least 8 weeks before study enrollment.

Exclusion Criteria

* Has previously received PPSV23 vaccine
* Has a history of active hepatitis within 3 months before study vaccination
* History of invasive pneumococcal disease within 3 years before study vaccination
Minimum Eligible Age

2 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

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Central Research Associates ( Site 0145)

Birmingham, Alabama, United States

Site Status

Velocity Clinical Research, Phoenix ( Site 0122)

Phoenix, Arizona, United States

Site Status

Madera Family Medical Group ( Site 0120)

Madera, California, United States

Site Status

Optumcare Colorado Springs, LLC ( Site 0113)

Colorado Springs, Colorado, United States

Site Status

Accel Research Sites Network- Nona Pediatric Center ( Site 0109)

Orlando, Florida, United States

Site Status

University of South Florida-Department of Pediatrics ( Site 0110)

Tampa, Florida, United States

Site Status

Velocity Clinical Research at Primary Pediatrics, Macon ( Site 0128)

Macon, Georgia, United States

Site Status

Bingham Memorial Hospital ( Site 0149)

Blackfoot, Idaho, United States

Site Status

Clinical Research Prime ( Site 0105)

Idaho Falls, Idaho, United States

Site Status

Clinical Research Prime Rexburg ( Site 0104)

Rexburg, Idaho, United States

Site Status

University of Louisville, Norton Children's Research Institute ( Site 0148)

Louisville, Kentucky, United States

Site Status

Velocity Clinical Research, Lafayette ( Site 0103)

Lafayette, Louisiana, United States

Site Status

Velocity Clinical Research, Gulfport ( Site 0115)

Gulfport, Mississippi, United States

Site Status

Velocity Clinical Research, Hastings ( Site 0114)

Hastings, Nebraska, United States

Site Status

Midwest Children's Health Research Institute ( Site 0117)

Lincoln, Nebraska, United States

Site Status

Midwest Children's Health Research Institute ( Site 0106)

Lincoln, Nebraska, United States

Site Status

Midwest Children's Health Research Institute-Research ( Site 0119)

Lincoln, Nebraska, United States

Site Status

Midwest Children's Health Research Institute-Research ( Site 0102)

Lincoln, Nebraska, United States

Site Status

Velocity Clinical Research, Albuquerque ( Site 0112)

Albuquerque, New Mexico, United States

Site Status

Velocity Clinical Research, Vestal ( Site 0121)

Vestal, New York, United States

Site Status

Epic Medical Research - Oklahoma ( Site 0134)

Chickasha, Oklahoma, United States

Site Status

Tribe Clinical Research, LLC-Pediatrics ( Site 0118)

Greenville, South Carolina, United States

Site Status

Tribe Clinical Research - Spartanburg ( Site 0108)

Spartanburg, South Carolina, United States

Site Status

Velocity Clinical Research, Austin ( Site 0129)

Austin, Texas, United States

Site Status

PanAmerican Clinical Research ( Site 0132)

Brownsville, Texas, United States

Site Status

Epic Medical Research ( Site 0133)

DeSoto, Texas, United States

Site Status

Epic Medical Research - Mesquite ( Site 0144)

Mesquite, Texas, United States

Site Status

Alliance for Multispecialty Research, LLC ( Site 0140)

Layton, Utah, United States

Site Status

Velocity Clinical Research, Salt Lake City ( Site 0124)

West Jordan, Utah, United States

Site Status

Canadian Center for Vaccinology ( Site 0004)

Halifax, Nova Scotia, Canada

Site Status

Premier Clinical Trial Network ( Site 0008)

Hamilton, Ontario, Canada

Site Status

Children's Hospital of Eastern Ontario ( Site 0001)

Ottawa, Ontario, Canada

Site Status

CHU Sainte-Justine ( Site 0007)

Montreal, Quebec, Canada

Site Status

McGill University Health Centre - Vaccine Study Centre ( Site 0005)

Pierrefonds, Quebec, Canada

Site Status

CHU de Québec-Université Laval ( Site 0006)

Québec, Quebec, Canada

Site Status

Centro de Estudios Clínicos (ICIM, Facultad de Medicina Clínica Alemana Universidad del Desarrollo)

Santiago, Region M. de Santiago, Chile

Site Status

Pontificia Universidad Catolica de Chile-Pediatric Infectious Diseases and Immunology ( Site 0209)

Santiago, Region M. de Santiago, Chile

Site Status

Hospital Roberto del Río-Infectología Pediátrica ( Site 0200)

Santiago, Region M. de Santiago, Chile

Site Status

Hospital Padre Hurtado-NEONATOLOGY/PEDIATRICS ( Site 0204)

Santiago, Region M. de Santiago, Chile

Site Status

Hospital Dr. Hernán Henríquez Aravena ( Site 0208)

Temuco, Región de la Araucanía, Chile

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Clinica Somer ( Site 0405)

Rionegro, Antioquia, Colombia

Site Status

Oncomedica S.A.S ( Site 0402)

Montería, Departamento de Córdoba, Colombia

Site Status

Fundación Valle del Lili ( Site 0404)

Cali, Valle del Cauca Department, Colombia

Site Status

CEIP - Centro de Estudios en Infectología Pediátrica ( Site 0401)

Cali, Valle del Cauca Department, Colombia

Site Status

FVR, Kokkolan rokotetutkimusklinikka ( Site 0602)

Kokkola, Keski-Pohjanmaa, Finland

Site Status

FVR, Oulun rokotetutkimusklinikka ( Site 0600)

Oulu, North Ostrobothnia, Finland

Site Status

FVR, Tampereen rokotetutkimusklinikka ( Site 0603)

Tampere, Pirkanmaa, Finland

Site Status

FVR, Seinäjoen rokotetutkimusklinikka ( Site 0604)

Seinäjoki, South Ostrobothnia, Finland

Site Status

FVR, Turun rokotetutkimusklinikka ( Site 0606)

Turku, Southwest Finland, Finland

Site Status

FVR, Espoon rokotetutkimusklinikka ( Site 0608)

Espoo, Uusimaa, Finland

Site Status

MeVac - Meilahti Vaccine Research Center ( Site 0609)

Helsinki, Uusimaa, Finland

Site Status

Centre Hospitalier Universitaire de Caen - Hôpital Côte de N-Centre de Recherche Clinique Pédiatriq

Caen, Calvados, France

Site Status

Hôpital Jeanne de Flandre ( Site 0702)

Lille, Nord, France

Site Status

Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universita

Paris, , France

Site Status

Rambam Health Care Campus ( Site 0900)

Haifa, , Israel

Site Status

Hadassah Mount Scopus Medical Centre ( Site 0902)

Jerusalem, , Israel

Site Status

Schneider Children's Medical Center ( Site 0903)

Petah Tikva, , Israel

Site Status

Saiseikai Yokohamashi Tobu Hospital ( Site 1714)

Yokohama, Kanagawa, Japan

Site Status

Okinawa Prefectural Nanbu Medical Center and Children's Medical Center ( Site 1701)

Kanegusuku, Okinawa, Japan

Site Status

Juntendo University Hospital ( Site 1700)

Bunkyo-ku, Tokyo, Japan

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Aquakids Clinic ( Site 1709)

Edogawa-ku, Tokyo, Japan

Site Status

Miyazaki Prefectural Miyazaki Hospital ( Site 1711)

Miyazaki, , Japan

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University of Miyazaki Hospital ( Site 1705)

Miyazaki, , Japan

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National Hospital Organization Okayama Medical Center ( Site 1713)

Okayama, , Japan

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Saitama Prefectural Children's Medical Center ( Site 1702)

Saitama, , Japan

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IN VIVO ( Site 1006)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Centrum Medyczne Pratia Bydgoszcz ( Site 1004)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckieg-Klinika Pediatrii i Chorob Infekcyjnyc

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

SZPZOZ im. Dzieci Warszawy w Dziekanowie Lesnym ( Site 1007)

Łomianki, Masovian Voivodeship, Poland

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Gravita Diagnostyka i Leczenie Niepłodności ( Site 1005)

Lodz, Łódź Voivodeship, Poland

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Hospital Germans Trias i Pujol ( Site 1104)

Badalona, Barcelona, Spain

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Hospital Sant Joan de Déu ( Site 1113)

Esplugues de Llobregat, Barcelona, Spain

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Hospital Universitari Vall d'Hebron ( Site 1115)

Barcelona, Catalonia, Spain

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CHUS - Hospital Clinico Universitario-Servicio de Pediatría ( Site 1111)

Santiago de Compostela, La Coruna, Spain

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Hospital Universitario Severo Ochoa ( Site 1114)

Leganés, Madrid, Spain

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Hospital Universitario La Paz-Pediatria y Enfermedades Infecciosas ( Site 1105)

Madrid, Madrid, Comunidad de, Spain

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Hospital Universitario 12 de Octubre-Unidad Pediátrica de Investigación y Ensayos Clínicos ( Site 11

Madrid, , Spain

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HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 1112)

Seville, , Spain

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CTC Karolinska ( Site 1201)

Solna, Stockholm County, Sweden

Site Status

Norrlands universitetssjukhus ( Site 1200)

Umeå, Västerbotten County, Sweden

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CTC GoCo ( Site 1202)

Mölndal, Västra Götaland County, Sweden

Site Status

Faculty of Medicine Siriraj Hospital-Pediatric Infectious Diseases ( Site 1601)

Bangkoknoi, Bangkok, Thailand

Site Status

Chulalongkorn University-Pediatrics ( Site 1602)

Pathumwan, Bangkok, Thailand

Site Status

Faculty of Tropical Medicine, Mahidol University - Vaccine Trial Centre ( Site 1604)

Ratchathewi, Bangkok, Thailand

Site Status

Songklanagarind hospital-Department of Pediatrics ( Site 1603)

Hat Yai, Changwat Songkhla, Thailand

Site Status

Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi-Pediatric Infection ( Site 1302)

Sarçam, Adana, Turkey (Türkiye)

Site Status

Hacettepe Universite Hastaneleri ( Site 1300)

Ankara, , Turkey (Türkiye)

Site Status

Ankara Universitesi Tip Fakultesi Hastanesi ( Site 1304)

Ankara, , Turkey (Türkiye)

Site Status

Ankara Bilkent Şehir Hastanesi-Infectious Disease and Clinical Microbiology ( Site 1301)

Ankara, , Turkey (Türkiye)

Site Status

Sisli Etfal Training and Research Hospital ( Site 1305)

Istanbul, , Turkey (Türkiye)

Site Status

Ege Universitesi Hastanesi ( Site 1306)

Izmir, , Turkey (Türkiye)

Site Status

Erciyes Universitesi Tıp Fakultesi Hastaneleri-pediatric infection ( Site 1303)

Kayseri, , Turkey (Türkiye)

Site Status

Countries

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United States Canada Chile Colombia Finland France Israel Japan Poland Spain Sweden Thailand Turkey (Türkiye)

Related Links

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Other Identifiers

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V116-013

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT2031230559

Identifier Type: REGISTRY

Identifier Source: secondary_id

2023-506236-32

Identifier Type: REGISTRY

Identifier Source: secondary_id

U1111-1293-4944

Identifier Type: REGISTRY

Identifier Source: secondary_id

V116-013

Identifier Type: -

Identifier Source: org_study_id

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