The Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications.

NCT ID: NCT06168708

Last Updated: 2023-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

220 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-07

Study Completion Date

2024-07-07

Brief Summary

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The aim of this clinical study is to evaluate the safety and efficacy of addition of gentamicin on irrigation fluid during trans-urethral resection of the prostate (TURP) and its role in reduction of post-TURP infectious complications.

the participants will be randomly divided into two groups: Group A (gentamicin group) and group B (Placebo).

Detailed Description

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220 patients scheduled for TURP for the management of urinary retention or LUTS will be included and divided into two groups; "Group A" includes 110 patients who will undergo TURP with addition of one ampoule of gentamicin 80 mg (2ml) /3L of irrigation solution (the first 9 Liters during resection and the first 6 Liters during post-operative irrigation) and "Group B" includes 110 patients who will undergo TURP with addition of normal saline (2 ml) as a placebo on the irrigation solution. Determination of Gentamicin in human serum using HPLC/UV after Chemical Derivatization will be done using the method of Barends et al (Barends, Brouwers, \& Hulshoff, 1987). Both groups will be compared as regards the demographic data, post-operative pyuria and bacteruria (1 week after removal of urethral catheter), fever, and/or sepsis.

Conditions

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Post-TURP Infectious Complications

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Garamicin group

the participants in this arm will undergo TURP with addition of one ampoule of gentamicin 80 mg (2ml) /3L of irrigation solution (the first 9 Liters during resection and the first 6 Liters during post-operative irrigation)

Group Type ACTIVE_COMPARATOR

Transurethral resection of the prostate (TURP)

Intervention Type PROCEDURE

TURP with addition of gentamicin on irrigation fluid to reduce infectious complications

Gentamicin

Intervention Type DRUG

gentamicin 80 mg (2ml) /3L of irrigation solution (the first 9 Liters during resection and the first 6 Liters during post-operative irrigation)

control group

the participants in this arm will undergo TURP with addition of normal saline (2 ml) on the irrigation solution (placebo).

Group Type PLACEBO_COMPARATOR

Transurethral resection of the prostate (TURP)

Intervention Type PROCEDURE

TURP with addition of gentamicin on irrigation fluid to reduce infectious complications

normal saline

Intervention Type DRUG

normal saline (2 ml) on the irrigation solution (placebo)

Interventions

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Transurethral resection of the prostate (TURP)

TURP with addition of gentamicin on irrigation fluid to reduce infectious complications

Intervention Type PROCEDURE

Gentamicin

gentamicin 80 mg (2ml) /3L of irrigation solution (the first 9 Liters during resection and the first 6 Liters during post-operative irrigation)

Intervention Type DRUG

normal saline

normal saline (2 ml) on the irrigation solution (placebo)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients with enlarged prostate presenting with LUTS or urine retention

Exclusion Criteria

* Unfit patients
* Renal impairment
* active UTI
* urethral strictures
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Zoeir

faculty of medicine, Tanta, ElGeish street, Egypt

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Urolgy Departement, Faculty of Medicine, Tanta University

Tanta, Outside U.S./Canada, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Ahmed G. Zoeir, Ph D

Role: CONTACT

Phone: +201008634198

Email: [email protected]

Ahmed A. Eissa, Ph D

Role: CONTACT

Phone: 01110304666

Email: [email protected]

Facility Contacts

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Ahmed G. Zoeir, Ph D

Role: primary

Other Identifiers

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35121/12/21

Identifier Type: -

Identifier Source: org_study_id