Is Size of Cisterna Magna Related to the Fetal Gender and Gestational Age

NCT ID: NCT06139978

Last Updated: 2025-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2024-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The cisterna magna (CM) is a large subarachnoid cerebrospinal space that lies between the caudal aspect ofthe cerebellum and the medulla oblongata, drainingthe fourth ventricle . The evaluation of the fetal cisterna magna is animportant part of obstetric ultrasound which targetsdetection of prenatal malformation of the fetal centralnervous system (CNS).Therefore, measuring the size ofthe cisterna magna has important clinical significancefor diagnosing fetal nervous system abnormalities.

Studies about the relationship between the anteroposterior diameter of the CM and the gestational age (GA) are still controversial. Some articles havepointed out that there was a good correlationbetween the diameter of the CM and GA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Prospective study that will include pregnant women who are between 20 weeks 0 days and 39 weeks 6 days of gestation. As in cross sectional study each fetus is considered only once. with use of magnetic resonance ultrasonography.( ultrasonography is a noninvasive imaging test uses high-frequency sound waves to create real-time pictures or video of internal organs or other soft tissues)

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Size of Cisterna Magna Gestational Age and Gender Conditions

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pregnant women in male fetus

Mesurment size of cisterna magna and ather fetal biometric using 2D US

ultrasound observation

Intervention Type BEHAVIORAL

The relationship between the anteroposterior diameter of the CM and the gestational age and gender

Pregnant women in female fetus

Mesurment size of cisterna magna and ather fetal biometric using 2D US

ultrasound observation

Intervention Type BEHAVIORAL

The relationship between the anteroposterior diameter of the CM and the gestational age and gender

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ultrasound observation

The relationship between the anteroposterior diameter of the CM and the gestational age and gender

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Pregnant women who are between 20 weeks 0 days and 39 weeks 6 days of gestation.
* Singleton pregnancy.

Exclusion Criteria

.gestational age can not be confirmed.

* Fetal malformations or intrauterine growthretardation
* Women with chronic diseases.
* bodymass index \>30
Minimum Eligible Age

16 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Assiut University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Alaa Gamal Abd El-Naser

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Elwany D Elsenousy, professor

Role: STUDY_CHAIR

Assiut medical school

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Assiut Medical School

Asyut, , Egypt

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Egypt

References

Explore related publications, articles, or registry entries linked to this study.

McMillan JJ, Williams B. Aqueduct stenosis. Case review and discussion. J Neurol Neurosurg Psychiatry. 1977 Jun;40(6):521-32. doi: 10.1136/jnnp.40.6.521.

Reference Type RESULT
PMID: 302852 (View on PubMed)

D'Antonio F, Khalil A, Garel C, Pilu G, Rizzo G, Lerman-Sagie T, Bhide A, Thilaganathan B, Manzoli L, Papageorghiou AT. Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal ultrasound imaging (part 1): nomenclature, diagnostic accuracy and associated anomalies. Ultrasound Obstet Gynecol. 2016 Jun;47(6):690-7. doi: 10.1002/uog.14900. Epub 2016 May 10.

Reference Type RESULT
PMID: 25970099 (View on PubMed)

Volpe P, Contro E, De Musso F, Ghi T, Farina A, Tempesta A, Volpe G, Rizzo N, Pilu G. Brainstem-vermis and brainstem-tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis. Ultrasound Obstet Gynecol. 2012 Jun;39(6):632-5. doi: 10.1002/uog.11101. Epub 2012 May 14.

Reference Type RESULT
PMID: 22253138 (View on PubMed)

Araujo Junior E, Passos AP, Bruns RF, Nardozza LM, Moron AF. Reference range of fetal cisterna magna volume by three-dimensional ultrasonography using the VOCAL method. J Matern Fetal Neonatal Med. 2014 Jul;27(10):1023-8. doi: 10.3109/14767058.2013.847419. Epub 2013 Oct 22.

Reference Type RESULT
PMID: 24063432 (View on PubMed)

Araujo Junior E, Martins WP, Rolo LC, Pires CR, Zanforlin Filho SM. Normative data for fetal cisterna magna length measurement between 18 and 24 weeks of pregnancy. Childs Nerv Syst. 2014 Jan;30(1):9-12. doi: 10.1007/s00381-013-2298-y.

Reference Type RESULT
PMID: 24122018 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CM.sex & age

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.