Monkeypox, Biology, Outcome, Transmission and Epidemiology -Prospective Follow-up of High-risk Contacts

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

257 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-22

Study Completion Date

2024-10-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

With the MBOTE-CONTACT study, a detailed follow-up study of high-risk contacts of mpox patients will be done. The MBOTE-CONTACT study will be nested in the NIH-Funded PALM-007 clinical trial (NCT05559099) and the MBOTE project on mpox transmission. The study will take place in Maniema Province, Democratic Republic of Congo (DRC). Participants will be recruited among high-risk contacts of mpox patients included in the PALM-007 trial. Consenting contacts will be either followed daily at the central study site or visited weekly by an outreach team in the community. They will be examined daily for signs and symptoms and asked to provide daily saliva and weekly blood samples for polymerase chain reaction (PCR) and/or serology. If participants develop mpox, they are offered treatment and enrollment in the PALM-007 trial.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Monkeypox ASymptomatic Shedding: Evaluation by Self-Sampling MPX-ASSESS

NCT05443867

Monkey Pox

COMPLETED

Epidemiological and Clinical Characteristics of Human Mpox Outbreak in Equateur Province in the Democratic Republic of Congo (Part2)

NCT07067723

Monkeypox (Mpox)

ENROLLING_BY_INVITATION

Clinical and Biological Aspects of the MONKEYPOX Disease

NCT05627713

Monkey Pox

RECRUITING NA

Epidemiological and Clinical Characteristics of Human Mpox Outbreak in Equateur Province in the Democratic Republic of Congo (Part3)

NCT06984705

Mpox (Monkeypox)

ENROLLING_BY_INVITATION

Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC

NCT05734508

Monkeypox

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Mpox

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CROSSOVER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ▪ Be a high-risk contact of a laboratory-confirmed mpox case, with high-risk defined as having at least one the following types of exposure:
* living in the same household as an mpox patient
* having had sexual contact or intercourse with an mpox patient
* sleeping in the same room as an mpox patient
* sharing a meal with an mpox patient
* children: having played together

* Last exposure to the mpox index case of less than 14 days ago
* Patients of any age and gender (children aged \< 10 years are excluded from venous blood sampling)
* Patient or culturally acceptable representative is willing and able to give informed consent for participation in the study