Precision Cancer Therapy in Rare Cancers

NCT ID: NCT06119789

Last Updated: 2025-03-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-20

Study Completion Date

2036-08-01

Brief Summary

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Some rare cancers are hard-to-treat and patients have a poor prognosis. It is known that some of these patients have targetable molecular alterations, and some benefit from targeted drugs. However in many cases these drugs are not approved for the rare cancers.

In this study the aim is to do advanced molecular diagnostics to identify possible targets for therapy, and to treat accordingly.

Detailed Description

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All patients will have the tumour cells diagnosed with a large genepanel, analyzing more than 500 genes on DNA / RNA level. Patients will be treated based on the molecular characteristics of the tumor cells.

Conditions

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Rare Malignant Neoplasm

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

simon two stage model
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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treatment according to genetic alterations

treatment according to genetic alterations

Group Type EXPERIMENTAL

Imatinib

Intervention Type DRUG

imatinib treatment based on molecular alterations

Trametinib

Intervention Type DRUG

According to biomarkers

Dabrafenib

Intervention Type DRUG

According to biomarkers

Interventions

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Imatinib

imatinib treatment based on molecular alterations

Intervention Type DRUG

Trametinib

According to biomarkers

Intervention Type DRUG

Dabrafenib

According to biomarkers

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* ECOG 0-2,
* identified biomarker,
* reasonable biochemistry

Exclusion Criteria

* ECOG 3-5
* serious other diseases
Minimum Eligible Age

16 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Helse Stavanger HF

OTHER_GOV

Sponsor Role collaborator

University Hospital of North Norway

OTHER

Sponsor Role collaborator

StOlavs Hospital

UNKNOWN

Sponsor Role collaborator

Nordlandssykehuset HF

OTHER

Sponsor Role collaborator

Helse Nord-Trøndelag HF

OTHER

Sponsor Role collaborator

Sorlandet Hospital HF

OTHER_GOV

Sponsor Role collaborator

Møre og Romsdal Hospital Trust

OTHER

Sponsor Role collaborator

The Hospital of Vestfold

OTHER

Sponsor Role collaborator

Helse Fonna

OTHER

Sponsor Role collaborator

Haukeland University Hospital

OTHER

Sponsor Role collaborator

Sykehuset Ostfold

OTHER

Sponsor Role collaborator

Helse Forde

OTHER

Sponsor Role collaborator

Sykehuset Innlandet HF

OTHER

Sponsor Role collaborator

Oslo University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Åslaug Helland

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sigbjørn Smeland, MD PhD

Role: STUDY_CHAIR

Oslo University Hospital

Locations

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Oslo University Hospital

Oslo, , Norway

Site Status RECRUITING

Countries

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Norway

Central Contacts

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Åslaug Helland, MD PhD

Role: CONTACT

+4795940863

Kathinka Slørdahl, MD PhD

Role: CONTACT

Facility Contacts

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Åsa Öjlert, MD PhD

Role: primary

Katarina Puco, MD

Role: backup

Other Identifiers

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MATRIX-Rare

Identifier Type: -

Identifier Source: org_study_id

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