Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases

NCT ID: NCT02974803

Last Updated: 2021-08-20

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 6 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-02-09
• Study Completion Date: 2020-07-29

Brief Summary

Dabrafenib and trametinib are drugs that are usually given for the treatment of melanoma. Combinations of dabrafenib and trametinib have also been studied and when used together have shown to increase tumour shrinkage in animals compared to either drug alone. Dabrafenib and trametinib have also shown potential to penetrate the blood-brain-barrier when given together and have an effect on brain metastases. Giving these drugs at the same time and then giving brain stereotactic radiosurgery (SRS) may also be preferred in patients with brain metastases

Detailed Description

The purpose of this study is to find out the effects of giving dabrafenib in combination with trametinib continuously with stereotactic radiotherapy (SRS) has on melanoma and brain metastases.

Stereotactic Radiosurgery (SRS) is a non-surgical radiation therapy used to treat tumours of the brain. It can deliver precisely targeted radiation. Currently SRS alone is the usual treatment for patients with up to 4 brain lesions. This study will include 2 groups 1) patients with 1-4 brain lesions treated with SRS concurrently with dabrafenib and trametinib and 2) patients with 5-10 brain lesions treated with SRS concurrently with dabrafenib and trametinib.

Conditions

Melanoma; Brain Metastases

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dabrafenib and Trametinib

Dabrafenib, PO, 150mg BID Continuously Trameteinib, PO 2mg OD Continuously

Group Type: EXPERIMENTAL

Dabrafenib

Intervention Type: DRUG

Dabrafenib 150 mg twice a day until progression or unaccepted toxicity.

Trametinib

Intervention Type: DRUG

Trametinib 2 mg once daily until progression or unaccepted toxicity.

Interventions

Dabrafenib

Dabrafenib 150 mg twice a day until progression or unaccepted toxicity.

Intervention Type: DRUG

Trametinib

Trametinib 2 mg once daily until progression or unaccepted toxicity.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Histologically confirmed melanoma metastatic to brain and determined to be BRAF V600 mutated.
• Age ≥ 18 years.
• Karnofsky Performance Status of 70-100 (Appendix I).
• Patients must have a life expectancy of at least 12 weeks.
• Presence of measurable disease (i.e. present with at least one measurable CNS lesion per RECIST 1.1).
• Presence of 1-10 brain metastases as confirmed on a thin slice axial T1 post-gadolinium MRI sequence. The maximum diameter of a single brain lesion should be ≤ 4 cm and presence of a measurable lesion ≥ 1cm based on baseline MRI of brain.
• All CNS metastases amenable to single fraction SRS and or fractionated SRS. Hemorrhagic lesions are allowed if the treating radiation oncologist deems the lesion amenable to focal SRS.
• Able to swallow and retain oral medication and must not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels.
• Laboratory requirements (within 14 days prior to registration):

• ANC ≥ 1.2 x 10^9/L
• Hemoglobin ≥ 90 g/L
• Platelet count ≥ 100 x 10^9/L
• PT/INR & PTT ≤ 1.3 x ULN
• Total bilirubin ≤ 1.5 x ULN
• AST and ALT ≤ 2.5 x ULN
• Serum creatinine or ≤ 1.5 x ULN or Creatinine Clearance ≥ 50 ml/min (calculated by Cockcroft and Gault)
• LVEF ≥ LLN (within 28 days prior to registration)
• No prior treatment with a BRAF inhibitor or MEK inhibitor.
• No known ocular or primary mucosal melanoma.
• No prior systemic anti-cancer treatment within the last 2 weeks preceding the frist dose of dabrafenib and trametinib. Patients must have recoved from clinical manifestations of toxicity related to prior systemic therapy and have adequate washout as follows: Longest of one of the following:

• two weeks
• 5 half-lives for investigational agents
• Standard cycle length of standard therapies
• Prior systemic treatment in the adjuvant setting is allowed.
• No current use of a prohibited medication as described in section 7.2.
• No history of malignancy with confirmed activating RAS mutation at any time.
• No history of malignancy other than disease under study within 3 years of study enrollment.
• No leptomeningeal metastases or metastases causing spinal cord compression that are symptomatic or untreated or not stable for ≥ 3 months. Subjects on stable dose of corticosteroids > 2 weeks or who have been off of corticosteroids for at least 2 weeks can be enrolled with approval of CCTG.
• No serious or unstable pre-existing medical conditions, psychiatric disorders or other conditions that could interfere with the subject's safety, obtaining informed consent or compliance with study procedures.
• No history of Hepatitis B Virus or Hepatitis C Virus infection
• No history or evidence of cardiovascular risk No history or current eveidence/risk of retinal vein occlusion or central serous retinopathy
• No known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to the study treatments, their excipients, and/or dimethyl sulfoxide.
• No pregnant or lactating women.
• No hisotry of interstitial lung disease or active pneumonitis.
• Presence of any one brain metastases >4cm in maximal diameter, and/or presence of brain metastase of less than 1cm.
• No prior whole brain radiation
• No brainstem metastses
• No contrindications to MRI and/or Gadolinimum contrast or sterotactic brain radiation therapy.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Novartis

INDUSTRY

Sponsor Role: collaborator

Canadian Cancer Trials Group

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Arjun Sahgal

Role: STUDY_CHAIR

Odette Cancer Centre, Toronto, ON Canada

Teresa Petrella

Role: STUDY_CHAIR

Odette Cancer Centre, Toronto, ON Canada

Locations

QEII Health Sciences Centre

Halifax, Nova Scotia, Canada

Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, Canada

Odette Cancer Centre

Toronto, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

Centre hospitalier universitaire de Sherbrooke

Sherbrooke, Quebec, Canada

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, Canada

Countries

Canada

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

I224

Identifier Type: -

Identifier Source: org_study_id