Effect of Pursed-lips Breathing Combined With Aerobic Walking Exercise on Oxygenation and Activity Endurance in Lung Cancer Patients After Lobectomy

NCT ID: NCT06118164

Last Updated: 2023-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-22

Study Completion Date

2022-06-30

Brief Summary

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The effects of pursed-lip breathing or aerobic walking exercise in increasing muscle strength and motility and relieving dyspnea have been proved. However, patients with lung cancer often have decreased lung function and exercise capacity after lobectomy. The aim of this study was to explore the effects of pursed-lip breathing combined with aerobic walking exercise on postoperative oxygenation and exercise tolerance of lung cancer patients underwent lobectomy.

Detailed Description

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An randomized controlled trial was used. Sixty eligible subjects from the Department of Thoracic Surgery of a regional hospital in central Taiwan participate in this study. A total of sixty subjects were randomly and equally assigned to the experimental group, control group I and control group II, to carry out postoperative both pursed lip breathing and aerobic walking exercise, pursed lip breathing, and aerobic walking exercise respectively. All three interventions were conducted 3 times a day, each lasting 15 minutes, from the 1st to 5th day after the operation. Pretests were done before the start of the three interventions on the first postoperative day, and posttests were done after the completion of the three interventions on the 5th postoperative day. Data including 6-minute walking test, Dyspnea Visual Analogue Scale, Rating scale of perceived exertion, peak expiratory flow rate and SpO2 were collected.

Conditions

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Complications During Rehabilitation Stay

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The experimental group was given pursed-mouth breathing training combined with aerobic walking exercise.

Control group I was given pursed-mouth breathing training. Control group II was given aerobic walking exercise.
Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors
Patients who agreed to participate were randomly assigned to the experimental group or one of the two control groups (Control I and Control II) by outpatient nurses drawing lots from a lottery box. Once the group assignment was determined, on the day of admission, the researchers provided instructions on the respective intervention measures for that group (Pursed-lip breathing combined with aerobic walking exercise group, Pursed-lip breathing only group, Aerobic walking exercise only group). Data collection was carried out by registered nurses with at least two years of clinical experience in non-enrollment wards.

Study Groups

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experimental group -pursing- lip breathing combined with aerobic walking exercise

For the pursed-lip breathing combined with aerobic walking exercise group (experimental group), subjects were taught to coordinate their breathing with their walking. They were instructed to inhale for two steps and exhale with pursed lips for four to five steps. Initially, they were allowed to walk at a pace that felt comfortable to them, and then gradually increase their walking speed until they reached the target aerobic heart rate, calculated using the formula: (220 - age) × 55-65% of maximum heart rate.

During the walking exercise, a pulse oximeter was used to monitor their heart rate and blood oxygen saturation. Training sessions were conducted daily from the first day after surgery until the fifth day, with three sessions each day, and each session lasting for 15 minutes.

Group Type EXPERIMENTAL

pursing- lip breathing combined with aerobic walking exercise

Intervention Type BEHAVIORAL

pursing- lip breathing combined with aerobic walking exercise

Control group 1-pursed-lip breathing

For the group receiving single pursing- lip breathing training (control group 1), subjects were taught to perform deep inhalation through the nose (counting mentally from 1 to 2) while in a seated or standing position. They were then instructed to purse their lips and exhale slowly and steadily (counting mentally from 1 to 4).

During the walking exercise, a pulse oximeter was used to monitor their heart rate and blood oxygen saturation. Training sessions were conducted daily from the first day after surgery until the fifth day, with three sessions each day, and each session lasting for 15 minutes.

Group Type ACTIVE_COMPARATOR

pursing- lip breathing

Intervention Type BEHAVIORAL

pursing- lip breathing

Control group 2 -aerobic walking exercise

For the single aerobic walking exercise group (control group 2), subjects were taught to start with their own acceptable stride and pace and then gradually increase their walking speed until they reached the target aerobic heart rate. Pulse oximeters were used to monitor their heart rate and blood oxygen saturation levels during the process.

During the walking exercise, a pulse oximeter was used to monitor their heart rate and blood oxygen saturation. Training sessions were conducted daily from the first day after surgery until the fifth day, with three sessions each day, and each session lasting for 15 minutes.

Group Type ACTIVE_COMPARATOR

aerobic walking exercise

Intervention Type BEHAVIORAL

aerobic walking exercise

Interventions

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pursing- lip breathing combined with aerobic walking exercise

pursing- lip breathing combined with aerobic walking exercise

Intervention Type BEHAVIORAL

pursing- lip breathing

pursing- lip breathing

Intervention Type BEHAVIORAL

aerobic walking exercise

aerobic walking exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Participants aged over 20 who have been informed of the research process and are willing to participate and sign consent.
* Participants with clear consciousness, the ability to communicate in Mandarin or Taiwanese, and the ability to walk independently.
* Participants diagnosed with lung cancer who have undergone lung lobe resection surgery.

Exclusion Criteria

* Changes in the surgical plan, not undergoing at least a single lung lobe resection.
* Deterioration of postoperative condition, making it impossible to correctly perform pursed lip breathing or aerobic walking exercises.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taichung Tzu Chi Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jeng-Yuan Wu

Director of Thoracic Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hua-Shan Wu, PhD

Role: PRINCIPAL_INVESTIGATOR

Asia University

Locations

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Asia University

Taichung, Wufeng, Taiwan

Site Status

Countries

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Taiwan

References

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Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin. 2017 Mar;67(2):93-99. doi: 10.3322/caac.21388. Epub 2017 Jan 17.

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PMID: 31805526 (View on PubMed)

Granger CL, Edbrooke L, Denehy L. The nexus of functional exercise capacity with health-related quality of life in lung cancer: how closely are they related? Ann Transl Med. 2018 Dec;6(Suppl 2):S131. doi: 10.21037/atm.2018.12.35. No abstract available.

Reference Type RESULT
PMID: 30740452 (View on PubMed)

Kobayashi N, Kobayashi K, Kikuchi S, Goto Y, Ichimura H, Endo K, Sato Y. Long-term pulmonary function after surgery for lung cancer. Interact Cardiovasc Thorac Surg. 2017 May 1;24(5):727-732. doi: 10.1093/icvts/ivw414.

Reference Type RESULT
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Lugg ST, Agostini PJ, Tikka T, Kerr A, Adams K, Bishay E, Kalkat MS, Steyn RS, Rajesh PB, Thickett DR, Naidu B. Long-term impact of developing a postoperative pulmonary complication after lung surgery. Thorax. 2016 Feb;71(2):171-6. doi: 10.1136/thoraxjnl-2015-207697.

Reference Type RESULT
PMID: 26769017 (View on PubMed)

Li J, Guo NN, Jin HR, Yu H, Wang P, Xu GG. Effects of exercise training on patients with lung cancer who underwent lung resection: a meta-analysis. World J Surg Oncol. 2017 Aug 23;15(1):158. doi: 10.1186/s12957-017-1233-1.

Reference Type RESULT
PMID: 28835249 (View on PubMed)

Mayer AF, Karloh M, Dos Santos K, de Araujo CLP, Gulart AA. Effects of acute use of pursed-lips breathing during exercise in patients with COPD: a systematic review and meta-analysis. Physiotherapy. 2018 Mar;104(1):9-17. doi: 10.1016/j.physio.2017.08.007. Epub 2017 Aug 31.

Reference Type RESULT
PMID: 28969859 (View on PubMed)

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.

Reference Type RESULT
PMID: 33538338 (View on PubMed)

Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart. J Thorac Oncol. 2015 Sep;10(9):1240-1242. doi: 10.1097/JTO.0000000000000663. No abstract available.

Reference Type RESULT
PMID: 26291007 (View on PubMed)

Villeneuve PJ. Interventions to avoid pulmonary complications after lung cancer resection. J Thorac Dis. 2018 Nov;10(Suppl 32):S3781-S3788. doi: 10.21037/jtd.2018.09.26.

Reference Type RESULT
PMID: 30505565 (View on PubMed)

Ziarnik E, Grogan EL. Postlobectomy Early Complications. Thorac Surg Clin. 2015 Aug;25(3):355-64. doi: 10.1016/j.thorsurg.2015.04.003. Epub 2015 Jun 12.

Reference Type RESULT
PMID: 26210931 (View on PubMed)

Other Identifiers

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TaichungTCH

Identifier Type: -

Identifier Source: org_study_id

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