Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma

NCT ID: NCT06115408

Last Updated: 2024-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2024-08-31

Brief Summary

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This 2 arm randomized clinical trial will assess the impact of Dienogest and N-Acetyl Cysteine on volume reduction of uterine leiomyoma

Detailed Description

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Group A women will receive Dienogest orally 2mg pills daily for 3 months .20 cases Group B women will receive NAC orally at a dose of 600 mg/day for 3 months ,20 cases

Conditions

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Uterine Leiomyoma

Keywords

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Fibroids dienogest NAC

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study will be conducted on 40 women; they will be subdivided into 2equal groups .each group receive different intervention
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Caregivers

Study Groups

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Drug;Dienogest

2mg pills oral daily

Group Type EXPERIMENTAL

Dienogest 2 MG

Intervention Type DRUG

Clinical trial

Drug;N-Acetylcysteine

600 mg/day oral daily

Group Type EXPERIMENTAL

N-acetyl cysteine

Intervention Type DRUG

Clinical trial

Interventions

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Dienogest 2 MG

Clinical trial

Intervention Type DRUG

N-acetyl cysteine

Clinical trial

Intervention Type DRUG

Other Intervention Names

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Gynoprogest Gemacysteine

Eligibility Criteria

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Inclusion Criteria

1. Age: 20-45 years.
2. Women with uterine leiomyoma (sub-mucous, sub-serous or intramural) based on transvaginal sonography criteria. Uterine fibroids most often appear as concentric, solid, hypoechoic masses. This appearance results from the prevailing muscle, which is observed at histologic examination. These solid masses absorb sound waves and therefore cause a variable amount of acoustic shadowing.
3. Regular menstruation: regular period interval from 21 to 35 days.

Exclusion Criteria

1. Pregnant or menopausal women.
2. History of malignancies, metabolic, hematologic, cardiac, thromboembolism, diabetes, renal or hepatic diseases.
3. History of hormonal drug use or treatment for leiomyoma in the past 3 months.
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Esraa Mosaad Awd El-sayed

Researcher,ob/gyn Resident, Principal Investigator, Esraa Awd

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amr Mahmoud, lecturer

Role: STUDY_CHAIR

Ain Shams University

Ahmed mohamed mamdouh, assisstant professor

Role: STUDY_CHAIR

Ain Shams University

Locations

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Ainshams University

Cairo, , Egypt

Site Status

Countries

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Egypt

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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Leiomyoma volume reduction

Identifier Type: -

Identifier Source: org_study_id