Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer

NCT ID: NCT06111430

Last Updated: 2024-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-11

Study Completion Date

2026-04-10

Brief Summary

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Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity. Radiotherapy is usually the standard treatment of Head and neck cancers. In the present study, investigators aim to study the prevalence of cervical-cranial vascular complications during the early stages in these Head and neck cancer patients receiving Radiotherapy. Investigators will also compare the results between Nasopharyngeal cancer and other Head and neck cancerpatients receiving Radiotherapy.

Detailed Description

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Conditions

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Radiation Treatment Neurovascular Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Age ≥20 years.
2. Head and neck cancer patient .
3. Had ever received radiation therapy (RT) ≦ 72 months before inclusion in the registry.
4. Had ≥ 1 brain images and cervical-cranial vascular studies between the end of RT and d date of enrolment.


1. Age ≥20 years.
2. Head and neck cancer patient.
3. Had ever received radiation therapy (RT) \> 120 months before the adoption date of IRB at the participant site.
4. Had ≥ 2 brain images and cervical-cranial vascular studies between the end of RT and 6\~10 years after RT, one within 5 years after RT, the other after 5 years after RT.

Exclusion Criteria

1. Age \<20 years.
2. Patients not willing to sign the informed consent.

Population: Retrospective validation cohort


1.Age \<20 years.
Minimum Eligible Age

20 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chang Gung Memorial Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chi-Hung Liu

Role: CONTACT

(03)3281200 ext. 8340

Hui-Ching Kang

Role: CONTACT

(03)3281200 ext. 5214

Facility Contacts

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Chi-Hung Liu

Role: primary

033281200 ext. 8340

Hui-Ching Kang

Role: backup

033281200 ext. 5214

References

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Jiang JL, Chang JT, Huang BS, Chang TY, Sung PS, Wei YC, Lin CY, Yeh CH, Fan KH, Liu CH. Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer. BMC Cancer. 2025 Feb 11;25(1):235. doi: 10.1186/s12885-025-13647-6.

Reference Type DERIVED
PMID: 39934712 (View on PubMed)

Other Identifiers

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202200464B0

Identifier Type: -

Identifier Source: org_study_id

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