Identification of Biomarkers in Subjects With Coronary Syndrome (PLAQUE Study)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-06

Study Completion Date

2024-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study will to test the levels of innovative biomarkers, such as miRNAs, in the blood of subjects underwent to angioplasty procedure according to standard clinical practice.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Biomarkers and Unstable Carotid Plaque

NCT06887894

Carotid Artery Diseases

RECRUITING

Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest

NCT03149406

miRNAs Carotid Plaque

UNKNOWN

Physiopathological and Therapeutic Value of microRNA in the Progression of Carotid Artery Plaques: Carotid Protocol and microRNA

NCT02804659

Carotid Arteries

UNKNOWN

Lp-PLA2 and Coronary Atherosclerosis in Humans

NCT01557088

Coronary Atherosclerosis Endothelial Dysfunction

COMPLETED NA

Vascular Senescence and Atherosclerotic Plaque Vulnerability

NCT06313645

Coronary Artery Disease

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Twenty patients with acute coronary syndrome from non-ST-segment elevation myocardial infarction or with chronic coronary syndrome with clinical indication and favorable anatomy for coronary angioplasty will be enrolled. The angioplasty procedure will be performed according to standard clinical practice. Before and after angioplasty, blood samples will be taken upstream and downstream of the coronary lesion, arterial sampling will be performed at the level of the aortic root, and peripheral venous blood will be collected. MicroRNA expression will be analyzed in serum by next-generation sequencing (miRNome). Quantitative analysis of pro- and anti-inflammatory molecules such as IL-6 and the soluble form of IL-33 receptor (sST2) will be performed on various blood samples.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Coronary Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

subjects with clinical indication for coronary angioplasty

Twenty subjects with acute or chronic coronary syndrome that will be underwent to angioplasty procedure according to standard clinical practice.

blood sample collection

Intervention Type OTHER

Before and after angioplasty, blood samples upstream and downstream of the coronary lesion will be taken, arterial sampling at the aortic root level will be performed, and peripheral venous blood will be collected.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood sample collection

Before and after angioplasty, blood samples upstream and downstream of the coronary lesion will be taken, arterial sampling at the aortic root level will be performed, and peripheral venous blood will be collected.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinical indication for the PCI procedure according to the latest ESC (European Society of Cardiology) Guidelines
* Coronary stenosis treated with angioplasty must be located in the proximal segments of the three main vessels: IVA, CX and CD
* The vessels must have a diameter of their mid-distal section ≥ 3 mm
* Patients with NSTEMI ACS and clinical indication with favorable anatomy for coronary angioplasty, also called percutaneous coronary intervention (PCI), (for the ACS group)
* Patients with clinically incipient SCC with stable angina (or significant anginal equivalents) and clinical indication with favorable anatomy for PCI (for the SCC group)

Exclusion Criteria

* Contraindications to anticoagulant/antiplatelet therapy
* Extensive calcifications and/or tortuosity of the major epicardial segments
* Evidence of thrombotic occupation
* Patients with hemodynamic instability
* Patients with EF (ejection fraction) \< 35%
* Patients with severe chronic renal failure (e-GFR \< 30 mL/min)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No