Medical Access Program for Patritumab Deruxtecan

NCT ID: NCT06099639

Last Updated: 2025-06-08

Basic Information

• Recruitment Status: NO_LONGER_AVAILABLE
• Study Classification: EXPANDED_ACCESS

Brief Summary

The purpose of this Medical Access Program is to provide access to HER3-DXd for eligible patients with NSCLC who, in their treating physician's opinion, have an unmet clinical need which cannot be treated with approved and commercially available drugs and who cannot enter a clinical trial prior to commercial availability.

Detailed Description

This is a Medical Access Program which will be available to adult patients in the US with metastatic or locally advanced EGFRm NSCLC who have received at least 2 prior systemic therapies, who have no alternative commercially available treatment options, and are not able to enter a clinical trial.

In this Medical Access Program, eligible patients will be treated with HER3-DXd and will continue to receive treatment until any of the following occurs:

• Disease progression
• Unacceptable toxicity
• The benefit-risk no longer favors the individual
• HER3-DXd becomes commercially available in the US and reimbursement is approved for the concerned indication of the Medical Access Program.
• Withdrawal of consent
• Pregnancy
• Physician discretion
• Death

Conditions

Epidermal Growth Factor Receptor (EGFR)-Mutated Non Small Cell Lung Cancer

Interventions

HER3-DXd

5.6 mg/kg Q3W \[on Day 1 of each 21-day cycle\]) infused IV over approximately 90 minutes

Intervention Type: DRUG

Other Intervention Names

U3-1402

Eligibility Criteria

Inclusion Criteria

• Signed informed consent.
• Male or female aged ≥18 years (or local regulatory requirements).
• Histologically or cytologically documented locally advanced or metastatic EGFRm NSCLC not amenable to curative surgery or radiation.
• Documentation of radiological disease progression whilst on/after receiving most recent treatment regimen for locally advanced or metastatic disease. Patients must have received both of the following:

1. Prior treatment with any EGFR TKI, with at least one of them being osimertinib. Patients receiving an EGFR TKI at the time of signing informed consent should continue to take the EGFR TKI until 5 days prior to the first infusion of HER3 DXd.

2. Systemic therapy with at least 1 PBC regimen.

• Documentation of an EGFR-activating mutation detected from tumor tissue or blood (exon 19 deletion or L858R mutation).
• Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1 at the time of entering the Medical Access Program.
• Adequate levels of bone marrow reserve and organ function, based on local laboratory data, within 14 days prior to the first HER3-DXd infusion as specified in the MAP protocol.
• Female patients of childbearing potential must have a negative urine or serum pregnancy test at the time of entering the Medical Access Program and must be willing to use highly effective contraception during the treatment period and for at least 7 months following the last dose of HER3-DXd. Additionally, female patients must agree to not donate, or retrieve for their own use, eggs from the time of entering the Medical Access Program and throughout the treatment period, and for at least 7 months after the final HER3-DXd administration. Male patients with female partners who are able to become pregnant must be willing to use a highly effective form of contraception or avoid intercourse during the treatment period and for at least 4 months following the last dose of HER3- DXd. Additionally, male patients must agree not freeze or donate sperm from time of entering the Medical Access Program and throughout the treatment period, and for at least 4 months after final dose of HER3- DXd.
• Life expectancy of >3 months as determined by the treating physician.

• Treating physician must confirm that the patient is deriving continued benefit from treatment.
• Treating physician must confirm that all required safety information has been reported as per local laws/regulations.

Exclusion Criteria

• Patient is currently participating in or is in follow up for any Daiichi Sankyo ADC clinical trial including the HERTHENA-Lung02 'Trial of Patritumab Deruxtecan Initiated in Patients with EGFR-Mutated Metastatic Non-Small Cell Lung Cancer' (NCT05338970).
• Patient has previous or current histologic or cytologic evidence of small cell OR combined small cell/non-small cell disease in the archival tumor tissue or pre treatment tumor biopsy.
• Patient has any history of (non-infectious) ILD/pneumonitis that required steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis cannot be ruled out by imaging at the time of entering the Medical Access Program.
• Patient has clinically severe respiratory compromise (based on treating physician's assessment) resulting from intercurrent pulmonary illnesses including, but not limited to: a) any underlying pulmonary disorder, b) any autoimmune, connective tissue or inflammatory disorders, OR c) prior complete pneumonectomy.
• Inadequate washout period prior to the first HER3-DXd infusion as specified in protocol.
• Clinically significant unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE v5.0) Grade ≤1 or baseline. Patients with chronic Grade 2 toxicities may be eligible at the discretion of the treating physician after consultation with the designated Sponsor Medical Reviewer.
• Patient has clinically significant and/or uncontrolled cardiovascular disease prior to the first HER3-DXd infusion.
• Active hepatitis B virus (HBV) and/or hepatitis C virus infection, such as those with serologic evidence of viral infection within 28 days of the first HER3-DXd infusion.
• Human immunodeficiency virus (HIV) infection that is not well controlled as specified in the protocol.
• History of hypersensitivity to either the drug substance or any excipients in HER3-DXd.
• Female patient who is pregnant, breast-feeding, or intending to become pregnant.
• Prior or ongoing clinically relevant illness, medical condition, surgical history, physical finding, or laboratory abnormality that, in the treating physician's opinion, could affect the safety of the patient.
• Clinically significant corneal disease.
• Evidence of ongoing uncontrolled systemic bacterial, fungal, or viral infection. Note: Patients with localized fungal infections of skin or nails are eligible.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Daiichi Sankyo

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Program Team Lead

Role: STUDY_DIRECTOR

Daiichi Sankyo

Locations

Highlands Oncology

Springdale, Arkansas, United States

Southern California Permanente Medical Group

Los Angeles, California, United States

University of Colorado

Aurora, Colorado, United States

Yale-New Haven Hospital

New Haven, Connecticut, United States

Advent Health

Orlando, Florida, United States

University of Chicago Medical Center

Chicago, Illinois, United States

Block Medical Center

Skokie, Illinois, United States

Baptist Health Lexington

Lexington, Kentucky, United States

Karmanos Cancer Institute (Barbara Ann Karmanos Cancer Hospital)

Detroit, Michigan, United States

Mayo Clinic

Rochester, Minnesota, United States

The Washington University

St Louis, Missouri, United States

Overlook Medical Center

Summit, New Jersey, United States

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States

Kettering Health Cancer Center

New York, New York, United States

The Mount Sinai Hospital- (Icahn School of Medicine)

New York, New York, United States

Messino Cancer Center

Asheville, North Carolina, United States

Duke Cancer Institute

Durham, North Carolina, United States

Providence Portland Medical Center

Portland, Oregon, United States

The Kaiser Permanente Medical Group

Portland, Oregon, United States

Texas Oncology

Pearland, Texas, United States

Peace Health

Bellingham, Washington, United States

Countries

United States

Other Identifiers

U31402-0001-EAP-MA

Identifier Type: -

Identifier Source: org_study_id