UTAA09 Injection in the Treatment of Relapsed/Refractory Hematolymphatic Malignancies.

NCT ID: NCT06092047

Last Updated: 2025-05-16

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-10-01
• Study Completion Date: 2028-04-30

Brief Summary

This study is designed for exploring the preliminary safety and efficacy of the recombinant allogeneic healthy γδT cells transduced with the anti-CD19 lentiviral vector in patients with CD19-positive B cell hematolymphatic malignancies.

Detailed Description

A single arm open-label clinical study is designed to prelinarily determine the safety, efficacy, the ratio of CD19-positive cells in peripheral blood and cell kinetics after administration of UTAA09 injection in patients with CD19-positive relapsed/refractory B-cell hematolymphatic malignancies. All subjects will receive UTAA09 cells infusion.

Primary objective: explore the preliminary safety and efficacy of UTAA09 injection in patients with CD19-positive relapsed/refractory B-cell line hematolymphatic malignancies.

Secondary objectives:

1. explore the distribution, amplification and survival of UTAA09 cells in vivo after administration of UTAA09 injection;

2. explore the ratio of CD19-positive cells in peripheral blood after administration of UTAA09 injection.

Conditions

CD19-positive Relapsed or Refractory B-cell Malignancies

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

UTAA09 cells for infusion

Off-the-shelf γδT cells with a CD19-redirected Chimeric Antigen Receptor. Route of administration: Intravenous injection. Lymphodepleting conditioning regimen: A combination of fludarabine and cyclophosphamide will be administered at Day-7\~Day-2.

Group Type: EXPERIMENTAL

UTAA09 cells for infusion

Intervention Type: BIOLOGICAL

Intravenous injection, dosage:1-10×10\^8 CAR+ γδT cells, Cell concentration: 2×10\^7 cells/mL.

Fludarabine

Intervention Type: DRUG

30 mg/m\^2/day×4 days

Cyclophosphamide

Intervention Type: DRUG

1000 mg/m\^2/day×3 days

Interventions

UTAA09 cells for infusion

Intravenous injection, dosage:1-10×10\^8 CAR+ γδT cells, Cell concentration: 2×10\^7 cells/mL.

Intervention Type: BIOLOGICAL

Fludarabine

30 mg/m\^2/day×4 days

Intervention Type: DRUG

Cyclophosphamide

1000 mg/m\^2/day×3 days

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Patients aged between 3~70 (including cut-off values), regardless of gender and race;

2. Expected survival time>12 weeks;

3. ECOG score 0-2;

4. CD19-positive relapsed/refractory B-cell hematolymphatic malignancies;

5. Liver and kidney function, cardiopulmonary function meet the following requirements:

1. Creatinine ≤ 1.5 ULN;

2. Left ventricular ejection fraction ≥ 45%;

3. blood oxygen saturation>91%;

4. Total bilirubin ≤ 1.5 × ULN； ALT and AST ≤ 2.5 × ULN;

6. Be able to understand the trial and have signed the informed consent.

Exclusion Criteria

1. Those with graft-versus-host disease (GVHD) or requiring long-term systemic immunosuppressants;

2. Malignant tumors other than CD19-positive hematologic malignancies within 5 years prior to screening, except adequately treated cervical carcinoma in situ, basal cell or squamous epithelial cell skin cancer, local prostate cancer after radical resection, and breast ductal carcinoma in situ after radical resection;

3. Positive for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) and peripheral blood hepatitis B virus (HBV) DNA titer outside the normal reference range; Those who are positive for hepatitis C virus (HCV) antibodies and positive for hepatitis C virus (HCV) RNA in peripheral blood; Human immunodeficiency virus (HIV) antibody positive person; Positive for cytomegalovirus (CMV) DNA testing; those who test positive for syphilis;

4. Serious heart disease: including but not limited to unstable angina, myocardial infarction (within 6 months before screening), congestive heart failure (NYHA classification ≥ III), and serious arrhythmia;

5. Unstable systemic diseases judged by the investigator: including but not limited to severe liver, kidney or metabolic diseases requiring drug treatment;

6. Within 7 days before screening, there is active infection or uncontrollable infection requiring systemic treatment (except for mild genitourinary system infection and upper respiratory tract infection);

7. Pregnant or lactating women, female subjects who planned to conceive within 1 year of cell infusion or male subjects whose partner planned pregnancy within 1 year of their cell infusion;

8. Screening participants (except for inhalation or local use) who were receiving systemic steroid treatment within 7 days before screening or who were judged by the investigator to require long-term systemic steroid therapy during treatment;

9. Participated in other clinical studies within 3 month before screening;

10. There was evidence of central nervous system involvement at participant screening;

11. Conditions that the investigators considered unsuitable for enrollment.

• Minimum Eligible Age: 3 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Anhui Provincial Hospital

OTHER_GOV

Sponsor Role: collaborator

PersonGen BioTherapeutics (Suzhou) Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Xingbing Wang, MD

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital of USTC (Anhui Provincial Hospital)

Locations

The First Affiliated Hospital of USTC (AnHui Provincial Hospital)

Hefei, Anhui, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xingbing Wang, MD

Role: CONTACT

wangxingbing@ustc.edu.cn

13856007984

Facility Contacts

Xingbing Wang, MD

Role: primary

wangxingbing@ustc.edu.cn

+86 18963789012

Other Identifiers

PG-CART-UTAA09-001

Identifier Type: -

Identifier Source: org_study_id