NeuroN-QI: An Intervention to Promote Preterm Infants' Neurodevelopment

NCT ID: NCT06087744

Last Updated: 2024-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

124 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-23

Study Completion Date

2027-10-31

Brief Summary

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NeuroN-QI aims to evaluate the effects of an intervention consisting of periods of: 1) parents/preterm infants skin-to-skin contact and auditory stimulation by the parents's voice and 2) calm without manipulation with olfactory stimulation with breast milk in the incubator/bed both combined with appropriate light and noise levels to promote neurodevelopment preterm infants.

Detailed Description

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Conditions

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Neurodevelopmental Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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NeuroN-QI

Randomized dyads in the experimental group will be asked to do at least one session weekly (ideally 3) skin-to-skin contact (SSC) lasting 2 hours until the age of 36 weeks. Auditory sensory stimulation by mothers or fathers (reading a book) will be carried out during the first 10 minutes during the SSC sessions. The SSC will be followed by a period of calm and rest of one hour during which the infants will rest in their incubator with breast milk's olfactory stimulation. Light and sound control will be done during the entire intervention.

Group Type EXPERIMENTAL

NeuroN-QI

Intervention Type BEHAVIORAL

Skin-to-skin contact (SSC) lasting 2 hours with an auditory sensory stimulation followed by a period of calm and rest of one hour during which the infants will rest in their incubator with breast milk's olfactory stimulation. Light and sound control will be done during the entire intervention.

SSC alone

Randomized dyads in the control group will be asked to do at least one session weekly (ideally 3) skin-to-skin contact (SPC) lasting 2 hours until the corrected age of 36 weeks. During these sessions, light and noise levels will not be controlled or accompanied of auditory stimulation. SSC periods will not be followed by a calm and rest period with a olfactory stimulation.

Group Type ACTIVE_COMPARATOR

SSC alone

Intervention Type BEHAVIORAL

Skin-to-skin contact (SSC) lasting 2 hours

Interventions

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NeuroN-QI

Skin-to-skin contact (SSC) lasting 2 hours with an auditory sensory stimulation followed by a period of calm and rest of one hour during which the infants will rest in their incubator with breast milk's olfactory stimulation. Light and sound control will be done during the entire intervention.

Intervention Type BEHAVIORAL

SSC alone

Skin-to-skin contact (SSC) lasting 2 hours

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* born between 24 and 33 6/7 weeks GA;
* ready for SSC


* agree to do at least one SSC session/week combined with 10 min of auditory stimulation until 36 weeks of GA of their preterm infant;
* mothers express breast milk for their preterm infants

For twin births (twin pregnancies), fathers will also be invited to participate in the study, so that both infants can participate in the study.

Exclusion Criteria

* congenital anomalies or genetic disorders
* intraventricular hemorrhage \> grade II
* are small for GA defined as birth weight \<10th percentile
* on postnatal day 19 (maximum days targeted for study start)
* are still receiving analgesics, sedatives, paralyzing agents
* are under mechanical ventilation


* are aged \<18 years;
* have a physical condition that does not allow the SSC
* abuse illicit substances or alcohol that could influence stress, anxiety and parent- child interactions
* feed their preterm infant exclusively with commercial infant formula
* mothers had a breast surgery that could influence their breast milk production
* do not speak, read or write in French or in English
Minimum Eligible Age

24 Weeks

Maximum Eligible Age

34 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Justine's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Marilyn Aita

Researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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CHU Sainte-Justine

Montreal, Quebec, Canada

Site Status RECRUITING

CUSM

Montreal, Quebec, Canada

Site Status NOT_YET_RECRUITING

Countries

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Canada

Central Contacts

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Marilyn Aita, Ph.D.

Role: CONTACT

514-343-6111 ext. 51473

Kate St-Arneault, Ph.D (cand.)

Role: CONTACT

Facility Contacts

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Marilyn Aita

Role: primary

514-343-6111 ext. 51473

Jessica Duby

Role: primary

Other Identifiers

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MP-21-2023-5375

Identifier Type: -

Identifier Source: org_study_id

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