The TELENEO Trial: A Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals

NCT ID: NCT06087224

Last Updated: 2025-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

947 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-05

Study Completion Date

2029-05-01

Brief Summary

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The purpose of this study is to evaluate the impact of real-time audio-video telemedicine consults with a neonatologist (termed teleneonatology) on the early health outcomes of at-risk neonates delivered in community hospitals.

Detailed Description

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This prospective, multicenter trial will use a stepped wedge cluster randomized study design to evaluate the impact of real-time audio-video telemedicine consults with a neonatologist (termed "teleneonatology") on the risk of early mortality, early morbidity, and delivery room care for at-risk neonates delivered in community hospitals.

Conditions

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Death; Neonatal Morbidity;Newborn

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Stepped wedge cluster randomized trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Teleneonatology group

Study eligible neonates cared for by the community hospital team with telemedicine consultation by a neonatologist from the regional neonatal intensive care unit (NICU).

Group Type EXPERIMENTAL

Teleneonatology

Intervention Type OTHER

Real-time, two way, audio-video telemedicine connection between the neonatologist located in the regional neonatal intensive care unit (NICU) and the physician located at the community hospital.

Control group

Study eligible neonates cared for by the community hospital team per the site's usual practice of care.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Teleneonatology

Real-time, two way, audio-video telemedicine connection between the neonatologist located in the regional neonatal intensive care unit (NICU) and the physician located at the community hospital.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

GROUP 1: Community hospital clinicians

To be eligible to participate in this study, an individual must meet all of the following criteria:

1. A clinician who attends newborn resuscitations at a participating community hospital spoke site.
2. Provision of informed oral consent prior to any mandatory study specific procedures and analyses.


1. Preterm birth at less than 32 weeks' gestation at delivery; OR
2. Need for advanced resuscitation defined as:

1. positive pressure ventilation (PPV) initiated soon after birth and continued for at least 10 minutes; OR
2. placement of an alternative airway (endotracheal tube or laryngeal mask) to provide PPV; OR
3. chest compressions.

Exclusion Criteria

GROUP 1: Community hospital clinicians None

GROUP 2: At-risk outborn neonates

A neonate born in a participating community hospital spoke site who meets any of the following criteria will be excluded from the study:

1. Birth outside of the hospital birthing center.
2. Neonatal transport team present at time of birth and providing resuscitative care.
3. Severe congenital anomaly necessitating intensive care or surgery in the first two weeks of life.
4. Plan for comfort care (non-resuscitation) following delivery.
5. In-person neonatology-trained physician present for the resuscitation.
Minimum Eligible Age

0 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

Sponsor Role collaborator

Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Jennifer L. Fang

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jennifer Fang, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Bart M Demaerschalk, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Meegan G Van Straaten, MSPH

Role: STUDY_DIRECTOR

Mayo Clinic

Locations

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Providence Alaska Medical Center

Anchorage, Alaska, United States

Site Status RECRUITING

Bartlett Regional Hospital

Juneau, Alaska, United States

Site Status RECRUITING

PeaceHealth Ketchikan Medical Center

Ketchikan, Alaska, United States

Site Status RECRUITING

Mayo Clinic Arizona

Pheonix, Arizona, United States

Site Status ACTIVE_NOT_RECRUITING

Mayo Clinic Minnesota

Rochester, Minnesota, United States

Site Status ACTIVE_NOT_RECRUITING

Chickasaw Nation Medical Center

Ada, Oklahoma, United States

Site Status RECRUITING

Jackson County Memorial Hospital

Altus, Oklahoma, United States

Site Status RECRUITING

Great Plains Regional Medical Center

Elk City, Oklahoma, United States

Site Status RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Island Health

Anacortes, Washington, United States

Site Status RECRUITING

Providence Regional Medical Center Everett

Everett, Washington, United States

Site Status RECRUITING

Olympic Medical Center

Port Angeles, Washington, United States

Site Status RECRUITING

Seattle Children's Hospital

Seattle, Washington, United States

Site Status RECRUITING

University of Washington

Seattle, Washington, United States

Site Status RECRUITING

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington, United States

Site Status RECRUITING

Prairie Ridge Health

Columbus, Wisconsin, United States

Site Status RECRUITING

Fort HealthCare

Fort Atkinson, Wisconsin, United States

Site Status RECRUITING

University of Wisconsin-Madison

Madison, Wisconsin, United States

Site Status RECRUITING

Sauk Prairie Healthcare

Prairie du Sac, Wisconsin, United States

Site Status RECRUITING

Reedsburg Area Medical Center

Reedsburg, Wisconsin, United States

Site Status RECRUITING

Watertown Regional Medical Center

Watertown, Wisconsin, United States

Site Status RECRUITING

Stevenson Memorial Hospital

Alliston, Ontario, Canada

Site Status RECRUITING

William Osler Health System - Brampton Civic Hospital

Brampton, Ontario, Canada

Site Status RECRUITING

Michael Garron Hospital

East York, Ontario, Canada

Site Status RECRUITING

William Osler Health System - Etobicoke General Hospital

Etobicoke, Ontario, Canada

Site Status RECRUITING

Trillium Health Partners - Credit Valley Health

Mississauga, Ontario, Canada

Site Status RECRUITING

Southlake Regional Health Centre

Newmarket, Ontario, Canada

Site Status RECRUITING

Orillia Soldiers Memorial Hospital

Orillia, Ontario, Canada

Site Status RECRUITING

Scarborough Health Network - Centenary Hospital

Scarborough Village, Ontario, Canada

Site Status RECRUITING

Scarborough Health Network - General Hospital

Scarborough Village, Ontario, Canada

Site Status RECRUITING

North York General Hospital

Toronto, Ontario, Canada

Site Status RECRUITING

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status RECRUITING

Mount Sinai Hospital

Toronto, Ontario, Canada

Site Status RECRUITING

The Hospital for Sick Children

Toronto, Ontario, Canada

Site Status RECRUITING

Unity Health - St. Joseph's Health Centre

Toronto, Ontario, Canada

Site Status RECRUITING

Mackenzie Health - Cortellucci Vaughan Hospital

Vaughan, Ontario, Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Jennifer Fang, MD, MS

Role: CONTACT

5072669397

Bart M Demaerschalk, MD, MSc

Role: CONTACT

4803018000

Facility Contacts

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Teresa Lam, MD

Role: primary

907-562-2211

Mary-Alice Johnson, MD

Role: backup

Jessica Sperry, RN

Role: primary

907-796-8657

Kristin Fahey, RN

Role: primary

907-225-5171

Jonathan Walther, MD

Role: primary

(580) 436-3980

Bobby Saunkeah

Role: backup

Lindsey King, MD

Role: primary

580-379-5000

Courtney Allen, BSN

Role: primary

580-821-5326

Erin Bohon

Role: primary

405-271-5215

Jason Hogge, MD

Role: primary

360-299-1300

Mihai Puia-Dumitrescu, MD, MPH

Role: primary

207-838-9606

Laura Bullen, MD

Role: primary

360-477-9447

John Feltner

Role: primary

206-987-2599

John Feltner

Role: primary

206-543-3200

Brenda Baumeister, MD

Role: primary

509-662-1511 ext. 33131

Rachel Svendsen, RN

Role: primary

920-623-1299

Deborah Schumacher, RN

Role: primary

920-568-5000

Cassie Nelson

Role: primary

608-417-6236

Todd Schad, MD

Role: primary

608-643-3311

Anne Harris, MD

Role: primary

608-888-2696

Patricia Gedemer, RN

Role: primary

920-261-4210

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

Brenda Graydon

Role: backup

Ashley Mehta

Role: primary

1-416-813-7654

Ashley Mehta

Role: primary

1-416-813-7654

References

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Fang JL, Umoren R, Whyte H, Limjoco J, Makkar A, Yankanah R, McCoy M, Lo MD, Colby CE, Herrin J, Jacobson RM, Demaerschalk BM. Provider Perspectives on the Acceptability, Appropriateness, and Feasibility of Teleneonatology. Am J Perinatol. 2023 Oct;40(14):1521-1528. doi: 10.1055/a-1656-6363. Epub 2021 Sep 28.

Reference Type BACKGROUND
PMID: 34583392 (View on PubMed)

Fang JL, Whyte H, Umoren R, Limjoco J, Makkar A, Yankanah R, McCoy M, Lo MD, Herrin J, Demaerschalk BM. Accuracy of Simulated Research Tasks by Community Hospitals Participating in a Multicenter Telemedicine Trial. Telemed J E Health. 2022 Oct;28(10):1489-1495. doi: 10.1089/tmj.2021.0574. Epub 2022 Feb 15.

Reference Type BACKGROUND
PMID: 35167373 (View on PubMed)

Fang JL, Umoren RA, Whyte H, Limjoco J, Makkar A, Behl S, Lo MD, White L, Culjat M, Taylor JS, Kathuria S, Webb MO, Schad T, Shafranski S, Yankanah R, Herrin J, Demaerschalk BM. Evaluating the feasibility of a multicenter teleneonatology clinical effectiveness trial. Pediatr Res. 2023 Oct;94(4):1555-1561. doi: 10.1038/s41390-023-02659-2. Epub 2023 May 19.

Reference Type BACKGROUND
PMID: 37208433 (View on PubMed)

Related Links

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Other Identifiers

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R01HD112327

Identifier Type: NIH

Identifier Source: secondary_id

View Link

23-005502

Identifier Type: -

Identifier Source: org_study_id

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