Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-07

Study Completion Date

2029-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Investigating the Acute Effects of THC on Functional Brain Systems

NCT00628706

Reward Tetrahydrocannabinol Endocannabinoids +2 more

COMPLETED PHASE1

Cannabis Effects on Electroencephalography

NCT04316598

Healthy Volunteers

TERMINATED PHASE1

Cannabinoids for Pain Management and Neuroprotection From Concussion

NCT06204003

Healthy

RECRUITING PHASE1

Brain Activity Under the Influence of JWH

NCT06044415

Neurotransmission During JWH Intoxication

UNKNOWN NA

The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana

NCT00270803

Marijuana Dependence

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cannabis User

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Chronic cannabis users

Group Type EXPERIMENTAL

activity test

Intervention Type OTHER

Over 2 weeks, participants have to do a maximal progressive exercise and a 30 min constant exercise at 50% of maximal aerobic power

Healthy subjects

Group Type SHAM_COMPARATOR

activity test

Intervention Type OTHER

Over 2 weeks, participants have to do a maximal progressive exercise and a 30 min constant exercise at 50% of maximal aerobic power

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

activity test

Over 2 weeks, participants have to do a maximal progressive exercise and a 30 min constant exercise at 50% of maximal aerobic power

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Cannabis consumer group:

* Cannabis consumption \> 100 times in lifetime, last exposure \< 7 days, and recent exposure \> 10 times in the month.
* Positive toxicological urine test for ∆-9-THC.
* Having a cannabis use disorder according to the CAST.

Healthy group:

* Negative urine toxicological test for cannabis.
* No regular cannabis use for more than 6 months once in a lifetime.
* No cannabis consumption in the 6 months preceding the study.

Exclusion Criteria

For all subjects :

* Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
* Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
* Under medical treatment.
* Presence of diagnosed neurological disorders.
* Diagnosis of a psychotic picture entering axis I, DSM-5.
* Chronic progressive disease or in remission.
* Body mass index \> 30 kg/m2 (i.e. presence of obesity).

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes