ABL90 FP MC Neonatal Arterial, Venous, Capillary Blood

NCT ID: NCT06078943

Last Updated: 2023-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

612 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-17

Study Completion Date

2024-01-30

Brief Summary

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The goal of this clinical trial is to validate performance claims for method comparison for ABL90 FLEX PLUS in heparinized neonatal arterial, venous, and capillary whole blood for ctBil and FHbF in a Point of Care (POC) setting.

Detailed Description

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The main question it aims to answer is:

To quantify the relationship using comparison measurement from the same sample between the test device and the predicate device within the reportable range for ctBil and FHbF in heparinized arterial and venous neonatal whole blood in syringe measuring mode (S65, SP65) and heparinized mixed venous/arterial whole blood samples in capillary measuring mode (C65).

Conditions

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Congenital Heart Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Investigational Device

The test device in this clinical study is the ABL90 FLEX PLUS running SW3.5 MR2 manufactured by Radiometer Medical ApS The analyzer provides results for 17 parameters in 35 seconds using 65 µL heparinized whole blood. However, in this investigation only the data concerning the parameters ctBil and FHbF will be evaluated.

Group Type ACTIVE_COMPARATOR

method comparison

Intervention Type DEVICE

to quantify the relationship using comparison measurement from the same sample between ABL90 FLEX PLUS and the predicate device within the reportable range for all ctBil and FHbF in heparinized arterial and venous neonatal whole blood in syringe measuring mode (S65, SP65) and heparinized mixed venous/arterial whole blood samples in capillary measuring mode (C65)

Predicate device

The predicate device for this study is the unmodified device ABL90 FLEX PLUS (k160153) running software SW 3.1 MR7 including sensor casettes and solution packs versions corresponding to 2016.

ABL90 FLEX PLUS SW 3.1 MR7, has been selected as the predicate device because it has the appropriate 510(k) clearance, and the intended use matches the ABL90 FLEX PLUS SW. SW3.5 MR2 device.

Group Type SHAM_COMPARATOR

method comparison

Intervention Type DEVICE

to quantify the relationship using comparison measurement from the same sample between ABL90 FLEX PLUS and the predicate device within the reportable range for all ctBil and FHbF in heparinized arterial and venous neonatal whole blood in syringe measuring mode (S65, SP65) and heparinized mixed venous/arterial whole blood samples in capillary measuring mode (C65)

Interventions

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method comparison

to quantify the relationship using comparison measurement from the same sample between ABL90 FLEX PLUS and the predicate device within the reportable range for all ctBil and FHbF in heparinized arterial and venous neonatal whole blood in syringe measuring mode (S65, SP65) and heparinized mixed venous/arterial whole blood samples in capillary measuring mode (C65)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* The age of the subject must be ≤28 days.
* Subject evaluated as suitable according to the protocol to enroll in the study by principal investigator or designee.
* Subjects having a sample drawn as part of standard of care that meets the requirements for samples in this study.


• Delivery ≥38 weeks of gestation.

Exclusion Criteria

* Subject who has already provided successful results from arterial, venous and mixed venous/arterial samples, to cover both syringe modes and the capillary mode and parameters.
* Subjects exposed to the substances listed in Appendix 1 with last dose within 72 hours, should be excluded due to risk of interference.
* Subjects with known infectious disease such as Hepatitis C and HIV (in order to ensure the operator safety).


• Subjects positive of HIV or Hepatitis C
Minimum Eligible Age

1 Day

Maximum Eligible Age

28 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Radiometer Medical ApS

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dennis Dietzen, PhD

Role: PRINCIPAL_INVESTIGATOR

St. Louis Children's Hospital

Locations

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St Louis Children's Hospital

St Louis, Missouri, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Lone Pedersen, PhD

Role: CONTACT

+4528989640

Facility Contacts

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Dennis Dietzen, PhD, DABCC, FAACC

Role: primary

314-362-6586

Other Identifiers

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DC-083185

Identifier Type: -

Identifier Source: org_study_id

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