Influence of Air Pollution on SPondyloarthritis Flare-ups and Resistance to Treatment

NCT ID: NCT06077604

Last Updated: 2025-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

182 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-01

Study Completion Date

2024-10-15

Brief Summary

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The relationship between exposure to air pollution and spondyloarthritis (SpA) has been poorly studied. Based on data from the literature on other inflammatory pathologies such as rheumatoid arthritis, we hypothesize that there is a relationship between exposure to air pollution and the risk of presenting a flare-up in SpA patients following and living in Franche-Comté (France).

Primary objective:The potential relationship between exposure to air pollution (nitrogen dioxide, fine particles with a diameter of less than 10 or 2.5 microns and Ozone) and the onset of a spondyloarthritis flare-up will be explored in patients with this pathology.

Detailed Description

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Conditions

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Spondyloarthritis, Axial

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients with a diagnosis of Axial Spondyloarthritis

Patients with a diagnosis of Axial Spondyloarthritis, received in rheumatology consultation/hospitalization over the period 2019-2022 and living in Franche-Comté over the same period

Assessment of exposure to air pollution

Intervention Type OTHER

For each patient, exposure to air pollution will be assessed over a period immediately prior to any flare-up and over four periods at a distance from the flare-up.

Interventions

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Assessment of exposure to air pollution

For each patient, exposure to air pollution will be assessed over a period immediately prior to any flare-up and over four periods at a distance from the flare-up.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Axial Spondyloarthritis (radiographic or non-radiographic) according to Assessment of SpondyloArthritis international Society (ASAS) criteria
* Patient having received a consultation / hospitalization during the period 2019-2022
* Patient enrolled in the MISTIC cohort
* Having lived in Franche-Comté during the 2019-2022 period.

Exclusion Criteria

* Other chronic inflammatory rheumatism (rheumatoid arthritis according to ACR 2010 criteria or psoriatic arthritis according to ClASsification criteria for Psoriatic ARthritis criteria)
* No inflammatory rheumatic disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Besançon University Hospital

Besançon, Bourgogne-Franche-Comté, France

Site Status

Countries

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France

Other Identifiers

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2023/811

Identifier Type: -

Identifier Source: org_study_id

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