Trial Outcomes & Findings for Psychometric Testing: Cued vs. Learned Suppression (NCT NCT06074523)

NCT ID: NCT06074523

Last Updated: 2025-03-12

Results Overview

Reaction times on visual search task with positive, negative, and neutral cues

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 75 participants
• Primary outcome timeframe: 1 day
• Results posted on: 2025-03-12

Participant Flow

Participant milestones

Measure	Attention and Working Memory Tests All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report
Overall Study STARTED	75
Overall Study COMPLETED	65
Overall Study NOT COMPLETED	10

Reasons for withdrawal

Measure	Attention and Working Memory Tests All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report
Overall Study missing data in one condition, participant failed to fill out all data forms	9
Overall Study Withdrawal by Subject	1

Baseline Characteristics

Psychometric Testing: Cued vs. Learned Suppression

Baseline characteristics by cohort

Measure	Attention and Working Memory Tests n=75 Participants All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report
Age, Continuous	19.1 years STANDARD_DEVIATION 1.15 • n=5 Participants
Sex: Female, Male Female	42 Participants n=5 Participants
Sex: Female, Male Male	33 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	8 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	6 Participants n=5 Participants
Race (NIH/OMB) White	56 Participants n=5 Participants
Race (NIH/OMB) More than one race	3 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	2 Participants n=5 Participants
Region of Enrollment United States	75 participants n=5 Participants

PRIMARY outcome

Timeframe: 1 day

Population: 21 participants were excluded for either bad accuracy in one of the cognitive tasks (n = 11) or for incomplete data recording (n = 10).

Reaction times on visual search task with positive, negative, and neutral cues

Outcome measures

Measure	Attention and Working Memory Tests n=54 Participants All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report
Button Press Reaction Time Neutral Condition	1.86 Seconds Standard Deviation .77
Button Press Reaction Time Negative Condition	1.53 Seconds Standard Deviation .57
Button Press Reaction Time Positive Condition	1.29 Seconds Standard Deviation .49

PRIMARY outcome

Timeframe: 1 day

Population: 21 participants were excluded for either bad accuracy in one of the cognitive tasks (n = 11) or for incomplete data recording (n = 10).

Reaction times on visual search task no salient distractor and learned salient distractor

Outcome measures

Measure	Attention and Working Memory Tests n=54 Participants All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report
Learned Suppression Task Singleton Absent condition	1.014 Reaction time (seconds) Standard Deviation .315
Learned Suppression Task Singleton Present condition	1.001 Reaction time (seconds) Standard Deviation .294

PRIMARY outcome

Timeframe: 1 day

Population: 21 participants were excluded for either bad accuracy in one of the cognitive tasks (n = 11) or for incomplete data recording (n = 10).

Visual Working Memory Capacity- Change Localization; Estimate of number of items maintained in working memory

Outcome measures

Measure

Attention and Working Memory Tests n=54 Participants All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report

Visual Working Memory Capacity

2.85 Number of items remembered Standard Deviation .70

PRIMARY outcome

Timeframe: 1 day

Population: 21 participants were excluded for either bad accuracy in one of the cognitive tasks (n = 11) or for incomplete data recording (n = 10).

Adult Attention Deficit Hyperactivity Disorder (ADHD) Self Report Scale (used on healthy adults), Inattentive Traits subscale. Higher values indicate more ADHD-like inattentive trait symptoms (0-45).

Outcome measures

Measure

Attention and Working Memory Tests n=54 Participants All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report

Inattentive Traits Subscale of Adult Attention Deficit Hyperactivity Disorder (ADHD) Self Report Scale

18.1 units on scale Standard Deviation 5.40

Adverse Events

Attention and Working Memory Tests

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Measure

Attention and Working Memory Tests n=75 participants at risk All participants will complete a series of behavioral tasks, including cued visual search with positive (target color), negative (distractor color) and neutral (baseline) cues, learned visual search with a repeated salient distractor color, a visual working memory capacity task, and a daily life inattentive traits questionnaire (self-report). Single Arm. Behavioral Measurement and self-report: Measurements of behavioral performance and self-report

Nervous system disorders Participant Migraine

1.3% 1/75 • Number of events 1 • Participants were monitored during the testing session, which occurred during one day.

Additional Information

Nancy Carlisle

Lehigh University

Phone: 610-758-5122

Email: nbc415@lehigh.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place