Evaluation of Effectiveness of Two Different Doses of Mivacurium in Rapid Sequence Intubation
NCT ID: NCT06072534
Last Updated: 2024-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2023-09-01
2024-01-31
Brief Summary
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Detailed Description
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Aim of work Using high doses of mivacurium can provide accepted condition of emergency intubation within favorable time - monitoring hemodynamics changes during and after intubation, time of recovery from high doses of muscle relaxant
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
QUADRUPLE
Study Groups
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Miva 3
"Mivacurium chloride" ("Mivacron®") 0.3 mg/kg 3 times effective dose (ED) 95 iv during induction recording intubation condition during rapid sequence intubation within 90 sc monitoring hemodynamic changes during intubation ,time to recover to T1
"Mivacurium Chloride"
emergence modified sequence intubation
Miva 4
"Mivacurium chloride" ("Mivacron®") 0.4 mg/kg 4 times effective dose (ED) 95 iv during induction
recording intubation condition during rapid sequence intubation within 90 sc monitoring hemodynamic changes during intubation,time to recover to T1
"Mivacurium Chloride"
emergence modified sequence intubation
Interventions
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"Mivacurium Chloride"
emergence modified sequence intubation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* American society of anaesthesia (ASA) 1 and 2.
* Emergency surgery.
Exclusion Criteria
* allergy.
* neuromuscular disease.
* Suspected desaturation.
* Severe cardiac disease.
* Severe pulmonary disease.
20 Years
60 Years
ALL
No
Sponsors
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Al-Azhar University
OTHER
Responsible Party
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Ismail Mohamed Abdelgawad Ahmed
DOCTOR
Principal Investigators
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ismail m ahmed, professor
Role: PRINCIPAL_INVESTIGATOR
Al-Azhar University
Locations
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Al Azhar University
Cairo, Naser City, Egypt
Countries
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Central Contacts
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Facility Contacts
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References
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Savarese JJ, Ali HH, Basta SJ, Embree PB, Scott RP, Sunder N, Weakly JN, Wastila WB, el-Sayad HA. The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U). A short-acting nondepolarizing ester neuromuscular blocking drug. Anesthesiology. 1988 May;68(5):723-32. doi: 10.1097/00000542-198805000-00010.
Ostergaard D, Viby-Mogensen J, Rasmussen SN, Gatke MR, Pedersen NA, Skovgaard LT. Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically heterozygous for the usual and atypical plasma cholinesterase variants (UA). Acta Anaesthesiol Scand. 2003 Nov;47(10):1219-25. doi: 10.1046/j.1399-6576.2003.00243.x.
Plaud B, Marty J, Debaene B, Meistelman C, Pellissier D, LePage JY, Feiss P, Scherpereel P, Bouverne MN, Fosse S. The cardiovascular effects of mivacurium in hypertensive patients. Anesth Analg. 2002 Aug;95(2):379-84, table of contents. doi: 10.1097/00000539-200208000-00025.
Cooper R, Mirakhur RK, Clarke RS, Boules Z. Comparison of intubating conditions after administration of Org 9246 (rocuronium) and suxamethonium. Br J Anaesth. 1992 Sep;69(3):269-73. doi: 10.1093/bja/69.3.269.
Other Identifiers
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mivacurium in RSI
Identifier Type: -
Identifier Source: org_study_id
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