Follow up After TACE by Elastography and Color Doppler.
NCT ID: NCT06070623
Last Updated: 2023-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
54 participants
OBSERVATIONAL
2023-11-01
2025-12-31
Brief Summary
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Detailed Description
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Transarterial chemoembolization (TACE) is recommended as the first-line treatment in early stage patients with hepatocellular carcinoma (HCC) or as a palliative treatment modality in advanced patients with unresctable tumor which was known to increase survival rate. However, tumor control usually requires multiple TACE interventions due to the presence of residual and recurrent lesions.
Currently the Response Evaluation Criteria in Solid Tumors (RECIST) guideline was proposed as a method for measuring treatment response based on tumor shrinkage, which is a valuable measure of antitumor activity of cytotoxic drugs, Which adapted the concept of viable tumor-tumoral tissue showing uptake in arterial phase of contrast-enhanced MSCT abdomen.
Elastography can provide information about tumor stiffness to predict tumor response after TACE and detect any residual or recurrence.
We also use color Doppler in follow up to detect changes in portal pressure and hepatic artries hemodynamics of HCC patients after TACE. Mainly we search for changes in portal vein velocity {PVVel}, hepatic artery resistive index {HARI} and hepatic artery pulsitality index {HAPI}.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Interventions
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US
We use elastography and color Doppler from US machine and compare results with CT
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients with hepatic or perihepatic inflammations.
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Marco Moheb Samaan Drota
Dr at diagnostic and interventional radiology department - South Egypt cancer institute
Principal Investigators
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Mostafa Thabet, Prof Dr
Role: STUDY_DIRECTOR
Professor doctor at radiology department - Assiut University
Haysam Samy, Prof Dr
Role: STUDY_DIRECTOR
Professor doctor at radiology department - South Egypt cancer institute
Mohamed Elbaroudy, Ass. Prof Dr
Role: STUDY_DIRECTOR
Assistant professor doctor at radiology department - South Egypt cancer institute
Central Contacts
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References
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Tierney J, Baker J, Borgmann A, Brown D, Byram B. Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors. Sci Rep. 2019 Sep 10;9(1):13020. doi: 10.1038/s41598-019-49448-8.
Sato Y, Watanabe H, Sone M, Onaya H, Sakamoto N, Osuga K, Takahashi M, Arai Y; Japan Interventional Radiology in Oncology Study Group-JIVROSG. Tumor response evaluation criteria for HCC (hepatocellular carcinoma) treated using TACE (transcatheter arterial chemoembolization): RECIST (response evaluation criteria in solid tumors) version 1.1 and mRECIST (modified RECIST): JIVROSG-0602. Ups J Med Sci. 2013 Mar;118(1):16-22. doi: 10.3109/03009734.2012.729104. Epub 2012 Nov 20.
Hou S, Hua S, Cui K, Liu F, Ding K, Yuan J. The course and prognostic value of tumor stiffness detected by ultrasound elastography for transarterial chemoembolization of hepatocellular carcinoma. Quant Imaging Med Surg. 2023 Jun 1;13(6):3962-3972. doi: 10.21037/qims-22-292. Epub 2023 May 9.
Conti CB, Cavalcoli F, Fraquelli M, Conte D, Massironi S. Ultrasound elastographic techniques in focal liver lesions. World J Gastroenterol. 2016 Mar 7;22(9):2647-56. doi: 10.3748/wjg.v22.i9.2647.
Other Identifiers
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Elastography, Doppler in TACE.
Identifier Type: -
Identifier Source: org_study_id
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