Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline
NCT ID: NCT06069141
Last Updated: 2025-11-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
688 participants
INTERVENTIONAL
2024-01-01
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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single-dose BPG plus doxycycline
single-dose benzathine penicillin G (2.4 MU intramuscularly once) plus doxycycline (100 mg orally twice daily for 7 days)
Benzathine Penicillin G
Benzathine Penicillin G (2.4 MU intramuscularly once)
Doxycycline Capsule
doxycycline (100 mg orally twice daily for 7 days)
single-dose BPG
single-dose benzathine penicillin G (2.4 MU intramuscularly once)
Benzathine Penicillin G
Benzathine Penicillin G (2.4 MU intramuscularly once)
Interventions
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Benzathine Penicillin G
Benzathine Penicillin G (2.4 MU intramuscularly once)
Doxycycline Capsule
doxycycline (100 mg orally twice daily for 7 days)
Eligibility Criteria
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Inclusion Criteria
* Confirmed by a positive RPR titer with a reactive TPPA assay
Exclusion Criteria
* Exposure to antibiotics with activity against T. pallidum within the preceding 4 weeks (penicillin, 3rd cephalosporin, doxycycline, macrolides)
* A known or suspected infection requiring additional treatment with an antimicrobial active against T. pallidum (penicillin, 3rd cephalosporin, doxycycline, macrolides)
* Testing positive for C. trachomatis and M. genitalium, for which doxycycline or macrolide was administered
* A history of intolerance to penicillin or doxycycline
* PLWH have already participated in this study
* Pregnancy
18 Years
ALL
No
Sponsors
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National Taiwan University Hospital Hsin-Chu Branch
OTHER
Far Eastern Memorial Hospital
OTHER
Taipei Veterans General Hospital, Taiwan
OTHER_GOV
Taoyuan General Hospital
OTHER_GOV
National Cheng-Kung University Hospital
OTHER
Chi Mei Medical Hospital
OTHER
Kaohsiung Medical University Chung-Ho Memorial Hospital
OTHER
Kaohsiung Veterans General Hospital.
OTHER
National Taiwan University Hospital
OTHER
Responsible Party
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Locations
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National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Taiwan, Taiwan
Far Eastern Memorial Hospital
Taipei, Taiwan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan, Taiwan
Taipei Vetetrans General Hospital
Taipei, Taiwan, Taiwan
Taoyuan General Hospital
Taoyuan District, Taiwan, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, , Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung City, , Taiwan
Chi Mei Medical Hospital
Tainan, , Taiwan
National Cheng-Kung University Hospital
Tainan, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Kuan-Yin Lin
Role: backup
Other Identifiers
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202305061MINA
Identifier Type: -
Identifier Source: org_study_id
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