Antiplatelet Therapy for AIS Patients With Thrombocytopenia

NCT ID: NCT06053021

Last Updated: 2023-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-15

Study Completion Date

2026-01-01

Brief Summary

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The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia. Participants will be prescribed antiplatelet agents and followed up for 3 months.

Detailed Description

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Antiplatelet therapy is widely used in non-cardiogenic AIS patients for secondary prevention. However, it may also increase the risk of bleeding complications, especially in patients with thrombocytopenia. The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia. Participants will be prescribed antiplatelet agents and followed up for 3 months.

Conditions

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Acute Ischemic Stroke Thrombocytopenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Intervention

Participants will be prescribed antiplatelet agents including aspirin, clopidogrel, cilostazol, and dipyridamole.

Group Type EXPERIMENTAL

aspirin, clopidogrel, cilostazol, and dipyridamole

Intervention Type DRUG

Participants will be prescribed antiplatelet agents including aspirin, clopidogrel, cilostazol, and dipyridamole.

Interventions

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aspirin, clopidogrel, cilostazol, and dipyridamole

Participants will be prescribed antiplatelet agents including aspirin, clopidogrel, cilostazol, and dipyridamole.

Intervention Type DRUG

Other Intervention Names

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Antiplatelet Agents

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years old
* Acute ischemic stroke or transient ischemic attack with onset \< 7 days
* The last blood routine test before enrollment indicates platelet count \< 100 x 10\^9 and \> 30 x 10\^9

Exclusion Criteria

* Chronic renal dysfunction (GFR \< 30ml/min) or severe hepatic injury
* Indications for anticoagulation therapy, e.g. atrial fibrillation
* Myocardial infarction within 6 months before enrollment or received percutaneous coronary intervention in the past
* Have or plan to receive CEA or CAS in the following 3 months
* Life expectancy less than 1 year
* Plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding
* Pregnant or lactating women
* Individuals identified by researchers as unsuitable for participation in the study due to other reasons.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Min Lou, PhD

Role: CONTACT

+8613958007213

Facility Contacts

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Min Lou, PhD

Role: primary

8657187784811

Other Identifiers

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PERSIST

Identifier Type: -

Identifier Source: org_study_id

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