Enlighten Study: The EV-ICD Post Approval Registry

NCT ID: NCT06048731

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-01

Study Completion Date

2037-10-31

Brief Summary

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Medtronic is sponsoring Enlighten: The EV-ICD Post Approval Registry, to further confirm safety and effectiveness of EV-ICD in routine clinical practice, following commercial release of EV-ICD devices.

Detailed Description

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The Enlighten Study is a global, prospective, observational, multi-site registry study. This study is conducted within Medtronic's post-market surveillance platform.

Eligibility for enrollment is based on market release dates for EV-ICD System within the geography in which the subject is enrolled.

Patients enrolled in the Enlighten Study will be prospectively followed for the life time of device post-implant or until registry closure, patient death or patient exit from the registry (i.e., withdrawal of consent).

Successfully implanted patients are expected to have scheduled follow-up visits per routine clinical care, at least annually, or as prompted by reportable adverse events. The total estimated registry duration is through lifetime of device.

Conditions

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Ventricular Arrhythmia Tachycardia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Defibrillation using EV-ICD

Device: Defibrillation using the Extravascular ICD (EV-ICD)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient or legally authorized representative provides written authorization and/or consent per institution and geographical requirements
* Patient is intended to receive or be treated with a EV-ICD device System and must be enrolled prior to the EV-ICD device implant procedure

Exclusion Criteria

* Patient who is, or is expected to be, inaccessible for follow-up
* Patient is excluded by local local law
* Patient is currently enrolled or plans to enroll in any concurrent drug and/or device study that may confound the PSR results
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cardiology Associates Medical Group

Huntington Park, California, United States

Site Status

Sequoia Hospital

Redwood City, California, United States

Site Status

University of California San Diego

San Diego, California, United States

Site Status

Stanford Hospital & Clinics

Stanford, California, United States

Site Status

Hartford Hospital

Hartford, Connecticut, United States

Site Status

Clearwater Cardiovascular Consultants

Clearwater, Florida, United States

Site Status

Baptist Health

Jacksonville, Florida, United States

Site Status

Cardiovascular Institute of Northwest Florida

Panama City, Florida, United States

Site Status

Intercoastal Medical Group

Sarasota, Florida, United States

Site Status

Wellstar Research Institute

Marietta, Georgia, United States

Site Status

Deaconess Specialty Physicians

Newburgh, Indiana, United States

Site Status

Iowa Heart Center

West Des Moines, Iowa, United States

Site Status

Norton Heart and Vascular Institute

Louisville, Kentucky, United States

Site Status

TidalHealth Peninsula Regional

Salisbury, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Brigham and Woman's Hospital

Boston, Massachusetts, United States

Site Status

Sparrow Clinical Research Institute

Lansing, Michigan, United States

Site Status

Michigan Heart

Ypsilanti, Michigan, United States

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Metropolitan Cardiology Consultants

Coon Rapids, Minnesota, United States

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Minneapolis Heart Institute Foundation

Minneapolis, Minnesota, United States

Site Status

University of Minnesota Medical Center Fairview

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Saint Luke's Health System

Kansas City, Missouri, United States

Site Status

University of Kansas Medical Center Research Institute

Kansas City, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Virtua Health

Marlton, New Jersey, United States

Site Status

Atlantic Health System

Morristown, New Jersey, United States

Site Status

Presbyterian Heart Group

Albuquerque, New Mexico, United States

Site Status

Northwell Health South Shore University Hospital

Bay Shore, New York, United States

Site Status

Northwell Health Huntington Hospital

Huntington, New York, United States

Site Status

Northwell Health North Shore University Hospital

Manhasset, New York, United States

Site Status

Long Island Jewish Medical Center

New Hyde Park, New York, United States

Site Status

NYU Langone Medical Center

New York, New York, United States

Site Status

New York-Presbyterian Hospital Columbia University

New York, New York, United States

Site Status

New York - Presbyterian Hospital / Weill Cornell Medical Center

New York, New York, United States

Site Status

Hudson Valley Heart Center

Poughkeepsie, New York, United States

Site Status

Northwell Health Staten Island University Hospital

Staten Island, New York, United States

Site Status

Duke University Medical Center (DUMC)

Durham, North Carolina, United States

Site Status

The Christ Hospital Health Network CRD

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

Site Status

OhioHealth Research Institute (OHRI)

Columbus, Ohio, United States

Site Status

Saint Luke's University Health Network

Bethlehem, Pennsylvania, United States

Site Status

Geisinger Medical Center

Danville, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center UPMC Presbyterian

Pittsburgh, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center UPMC Shadyside

Pittsburgh, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center UPMC Passavant

Pittsburgh, Pennsylvania, United States

Site Status

Geisinger Wyoming Valley Medical Center

Wilkes-Barre, Pennsylvania, United States

Site Status

The Stern Cardiovascular Foundation

Memphis, Tennessee, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Saint Thomas Research Institute

Nashville, Tennessee, United States

Site Status

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, United States

Site Status

Consultants in Cardiology (Fort Worth)

Dallas, Texas, United States

Site Status

Heart Center of North Texas

Fort Worth, Texas, United States

Site Status

Baylor Research Institute

Plano, Texas, United States

Site Status

University of Virginia Medical Center

Charlottesville, Virginia, United States

Site Status

Aurora Cardiovascular Services

Milwaukee, Wisconsin, United States

Site Status

LKH - Universitätsklinikum Graz

Graz, , Austria

Site Status

Aö Landeskrankenhaus - Universitätskliniken Innsbruck

Innsbruck, , Austria

Site Status

Kepler Universitätsklinikum Med Campus III

Linz, , Austria

Site Status

Allgemeines Krankenhaus - Universitätskliniken Wien

Vienna, , Austria

Site Status

AZ Sint Jan Brugge-Oostende av

Bruges, , Belgium

Site Status

Cliniques Universitaires Saint-Luc

Brussels, , Belgium

Site Status

University Of Calgary

Calgary, Alberta, Canada

Site Status

Montreal Heart Institute

Montreal, Quebec, Canada

Site Status

Institut Universitaire de Cardiologie et de Pneumo

Québec, Quebec, Canada

Site Status

McGill University Health Centre (MUHC)

Montreal, , Canada

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Nemocnice Na Homolce

Prague, , Czechia

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Rigshospitalet

Copenhagen, , Denmark

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Odense Universitetshospital

Odense, , Denmark

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Helsinki University Hospital

Helsinki, , Finland

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Centre Hospitalier Universitaire de Clermont-Ferrand - Gabriel-Montpied

Clermont-Ferrand, , France

Site Status

Centre Hospitalier Universitaire de Grenoble - Site Nord

La Tronche, , France

Site Status

Centre Hospitalier Régional Universitaire de Lille

Lille, , France

Site Status

OC Santé - Clinique du Millénaire

Montpellier, , France

Site Status

Hôpital Guillaume et René Laënnec - CHU de Nantes

Nantes, , France

Site Status

Hopital Pitie-Salpetriere AP-HP

Paris, , France

Site Status

Hôpital Européen Georges Pompidou

Paris, , France

Site Status

Institut Mutualiste Montsouris

Paris, , France

Site Status

Hôpital Haut-Lévêque - CHU de Bordeaux

Pessac, , France

Site Status

CHU de Rennes - Hôpital Pontchaillou

Rennes, , France

Site Status

CHRU de Tours - Hôpital Trousseau

Saint-Avertin, , France

Site Status

Herz- und Diabeteszentrum NRW - Ruhr-Universität Bochum

Bad Oeynhausen, , Germany

Site Status

Elektrophysiologie Bremen - Im Klinikum Links der Weser

Bremen, , Germany

Site Status

Medizinische Hochschule Hannover

Hanover, , Germany

Site Status

Robert-Bosch-Krankenhaus

Stuttgart, , Germany

Site Status

Eberhard Karls Universität Tübingen - Universitätsklinikum Tübingen

Tübingen, , Germany

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Hippokration General Hospital of Athens

Athens, , Greece

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George Papanikolaou General Hospital

Thessaloniki, , Greece

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Prince of Wales Hospital

Hong Kong, , Hong Kong

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Semmelweis Egyetem AOK

Budapest, , Hungary

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Shaare Zedek Medical Center

Jerusalem, , Israel

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Sheba Medical Center

Ramat Gan, , Israel

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Azienda Ospedaliera - Universitaria Consorziale Policlinico di Bari

Bari, , Italy

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Policlinico Di Sant Orsola Malpighi

Bologna, , Italy

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Azienda Ospedaliera Ospedale Niguarda Cà Granda

Milan, , Italy

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Centro Cardiologico Monzino

Milan, , Italy

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Azienda Ospedaliera San Gerardo

Monza, , Italy

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Chest Disease Hospital

Kuwait City, , Kuwait

Site Status

Amsterdam UMC - Locatie AMC

Amsterdam, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

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Universitair Medisch Centrum Groningen

Groningen, , Netherlands

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Leids Universitair Medisch Centrum (LUMC)

Leiden, , Netherlands

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St Antonius Ziekenhuis

Nieuwegein, , Netherlands

Site Status

Erasmus Medisch Centrum

Rotterdam, , Netherlands

Site Status

HagaZiekenhuis - Locatie Leyweg

The Hague, , Netherlands

Site Status

Christ Church Hospital

Christchurch, , New Zealand

Site Status

Uniwersytecki Szpital Kliniczny w Poznaniu

Poznan, , Poland

Site Status

Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego

Warsaw, , Poland

Site Status

Narodowy Instytut Kardiologii - Stefana kardynała Wyszyńskiego

Warsaw, , Poland

Site Status

Slaskie Centrum Chorob Serca

Zabrze, , Poland

Site Status

Centro Hospitalar de Lisboa Ocidental, E.P.E. Hospital de Santa Cruz

Carnaxide, , Portugal

Site Status

Hospital de Santa Maria-Centro Hospitalar Lisboa Norte, EPE

Lisbon, , Portugal

Site Status

King Fahad Armed Forces Hospital

Jeddah, , Saudi Arabia

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King Faisal Specialist Hospital & Research Centre

Riyadh, , Saudi Arabia

Site Status

Hospital Universitario da Coruña

A Coruña, , Spain

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Hospital Universitari Bellvitge

Barcelona, , Spain

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Hospital Universitario Reina Sofía

Córdoba, , Spain

Site Status

Hospital Universitari de Girona Doctor Josep Trueta

Girona, , Spain

Site Status

Hospital Universitario Virgen de las Nieves

Granada, , Spain

Site Status

Hospital Universitario Son Espases

Palma de Mallorca, , Spain

Site Status

Hospital Universitario y Politécnico La Fe

Valencia, , Spain

Site Status

Sahlgrenska Universitetssjukhuset

Gothenburg, , Sweden

Site Status

Skånes Universitetssjukhus

Skåne, , Sweden

Site Status

Universitätsspital Basel

Basel, , Switzerland

Site Status

Inselspital - Universitätsspital Bern

Bern, , Switzerland

Site Status

Centre Hospitalier Universitaire Vaudois

Lausanne, , Switzerland

Site Status

Istituto Cardiocentro Ticino

Lugano, , Switzerland

Site Status

UniversitätsSpital Zürich

Zurich, , Switzerland

Site Status

Glenfield Hospital

Leicester, , United Kingdom

Site Status

Kings College Hospital NHS Foundation Trust

London, , United Kingdom

Site Status

Countries

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United States Austria Belgium Canada Czechia Denmark Finland France Germany Greece Hong Kong Hungary Israel Italy Kuwait Netherlands New Zealand Poland Portugal Saudi Arabia Spain Sweden Switzerland United Kingdom

References

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Boersma LVA, Amin A, Clementy N, Duncker D, Engel G, Epstein L, Kuriachan V, Frazier-Mills C, Gwechenberger M, Nishii N, Lande J, Wiggenhorn C, Crozier I. Design of a post-market registry for the extravascular implantable cardioverter-defibrillator: The Enlighten Study. Heart Rhythm O2. 2024 Oct 16;6(1):64-69. doi: 10.1016/j.hroo.2024.09.022. eCollection 2025 Jan.

Reference Type DERIVED
PMID: 40224263 (View on PubMed)

Other Identifiers

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PSR: EV-ICD PAS/PMCF

Identifier Type: -

Identifier Source: org_study_id

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