Home-Monitoring in Implantable Cardioverter Defibrillator (ICD) Patients

NCT ID: NCT00787683

Last Updated: 2012-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

416 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-31

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to investigate the cost-effectiveness and effectiveness of remote-monitoring compared to standard care in patients with implantable cardioverter defibrillator.

Detailed Description

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Implantable cardioverter defibrillator (ICD) are an important and effective treatment in patients at risk of sudden cardiac death. In order to allow for a more continuous follow-up and reduced complication rates of patients with ICD, new devices including remote-monitoring (home-monitoring) features of patients with ICD have been developed. BIOTRONIK Home Monitoring service enables the doctors to safely follow up their patients with implanted cardioverter-defibrillators in a remote fashion, with fewer in-clinic consultations. This may result in a more efficient follow-up and cost-savings for the health care payer.

The objective of the current study is to investigate the cost-effectiveness and effectiveness of home-monitoring compared to standard care.

Conditions

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Ventricular Arrythmias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Home-monitoring

Patients receive an additional home-monitoring (remote-monitoring) device (CardioMessengerII) following Biotronik Lumax ICD implantation. The device enables regular transmission and examination of ICD information via home-monitoring. Follow-up appointments in outpatient clinic are changed compared to standard care. While follow-up 1, 12, and 24 months after ICD implantation consist of outpatient clinic appointments, follow-up 3, 6, and 18 months after ICD implantation are conducted remotely.

Group Type EXPERIMENTAL

Home-monitoring provided by LUMAX ICD device and CardioMessenger II

Intervention Type DEVICE

All study participants receive an ICD of the Biotronik lumax family. Only participants of the intervention group receive the CardioMessengerII to allow for transmission of regular home monitoring messages. All study participants will be followed for 12 to 24 months (depending on the time of recruitment). The intervention and comparison to be investigated is home-monitoring vs. no home-monitoring. The intervention involves a combination of in-clinic consultations and regular use of home-monitoring services. As part of the modified follow-up schedule of intervention patients compared to standard care, follow-up in-clinic consultations 3, 6, and 18 months after ICD implantation will be replaced by home-monitoring follow-up.

Standard care

Patients randomised to the standard care group receive no home-monitoring device (CardioMessengerII) following Lumax ICD implantation. Patients have scheduled follow-up appointments at the ICD outpatient clinics at 1, 3, 6, 12, 18, and 24 months after ICD implantation.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Home-monitoring provided by LUMAX ICD device and CardioMessenger II

All study participants receive an ICD of the Biotronik lumax family. Only participants of the intervention group receive the CardioMessengerII to allow for transmission of regular home monitoring messages. All study participants will be followed for 12 to 24 months (depending on the time of recruitment). The intervention and comparison to be investigated is home-monitoring vs. no home-monitoring. The intervention involves a combination of in-clinic consultations and regular use of home-monitoring services. As part of the modified follow-up schedule of intervention patients compared to standard care, follow-up in-clinic consultations 3, 6, and 18 months after ICD implantation will be replaced by home-monitoring follow-up.

Intervention Type DEVICE

Other Intervention Names

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Home-monitoring Remote-monitoring Tele-monitoring ICD Biotronik Lumax CardioMessenger

Eligibility Criteria

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Inclusion Criteria

* The patient is willing/able to undergo the study protocol appointments and procedures/questionnaires
* Indication for implantation of single chamber ICD or dual chamber ICD according to European guidelines

Exclusion Criteria

* Age \< 18 and \> 80 years
* Expected non-compliance
* Known drug or alcohol abuse
* Life expectancy \< 1 year
* NYHA classification IV
* Participation in another clinical study
* Participation in another telemonitoring concept
* Pregnant or breast-feeding woman
* Uncontrolled hypertension
* No mobile phone use possible in patient residence
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biotronik SE & Co. KG

INDUSTRY

Sponsor Role collaborator

F. Mueller-Riemenschneider

OTHER

Sponsor Role lead

Responsible Party

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F. Mueller-Riemenschneider

PD, Dr.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Markus Zabel, Prof., MD

Role: PRINCIPAL_INVESTIGATOR

Medical Faculty, University of Göttingen, Germany

Locations

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Asklepios Hospital Barmbeck in Hamburg

Hamburg, City state of Hamburg, Germany

Site Status

Hospital Bremerhaven

Bremerhaven, Lower Saxony, Germany

Site Status

MH-Hannover

Hanover, Lower Saxony, Germany

Site Status

University Hospital Aachen

Aachen, North Rhine-Westphalia, Germany

Site Status

Cardiological Practice

Bonn, North Rhine-Westphalia, Germany

Site Status

St. Vincenz Hospital Paderborn

Paderborn, North Rhine-Westphalia, Germany

Site Status

University Hospital Schleswig-Holstein

Lübeck, Schleswig-Holstein, Germany

Site Status

Hospital Bad Berka

Bad Berka, , Germany

Site Status

Hospital Coburg

Coburg, , Germany

Site Status

University Hospital Göttingen

Göttingen, , Germany

Site Status

Heart Centre Bodensee Konstanz

Konstanz, , Germany

Site Status

University Hospital Münster

Münster, , Germany

Site Status

Academic Teaching Hospital Villingen of the University of Freiburg

Villingen-Schwenningen, , Germany

Site Status

Countries

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Germany

References

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Zabel M, Muller-Riemenschneider F, Geller JC, Brachmann J, Kuhlkamp V, Dissmann R, Reinhold T, Roll S, Luthje L, Bode F, Eckardt L, Willich SN; MONITOR-ICD investigators. Rationale and design of the MONITOR-ICD study: a randomized comparison of economic and clinical effects of automatic remote MONITORing versus control in patients with Implantable Cardioverter Defibrillators. Am Heart J. 2014 Oct;168(4):430-7. doi: 10.1016/j.ahj.2014.04.021. Epub 2014 Jun 13.

Reference Type DERIVED
PMID: 25262251 (View on PubMed)

Other Identifiers

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V7.0

Identifier Type: -

Identifier Source: org_study_id

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