To Evaluate the Safety and Efficacy of Human BCMA Targeted CAR-NK Cells Injection for Subjects With R/R MM or PCL

NCT ID: NCT06045091

Last Updated: 2023-09-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-04
• Study Completion Date: 2027-09-30

Brief Summary

This study is a single-arm, open-label, dose-escalation trial to explore the safety, tolerability and pharmacokinetic/pharmacodynamics characteristics of human BCMA targeted CAR-NK Cells injection, and to preliminarily observe the efficacy of the trial drug in patients with relapsed/refractory multiple myeloma or plasma cell leukemia.

Detailed Description

Subjects with relapsed/refractory multiple myeloma or plasma cell leukemia can participate if all eligibility criteria are met. Tests required to determine eligibility including disease assessments, a physical exam, Electrocardiograph, Computed tomography (CT)/Magnetic Resonance Imaging (MRI)/Positron Emission Tomography (PET), liver/renal function tests, complete blood count with differential and complete metabolic profile and etc. Subjects will receive preconditioning chemotherapy prior to the first infusion of human BCMA targeted CAR-NK Cells injection. After the infusion, subjects will be followed for adverse events, pharmacokinetic/pharmacodynamics characteristics, efficacy of human BCMA targeted CAR-NK cells. Study procedures may be performed while hospitalized.

Conditions

Multiple Myeloma; Plasma Cell Leukemia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Human BCMA Targeted CAR-NK Cells Injection

Two doses on Day 0 and Day 7. 1.5×10\^8 CAR+NK cells/dose, 3.0×10\^8 CAR+NK cells/dose or 6.0×10\^8 CAR+NK cells/dose

Group Type: EXPERIMENTAL

Human BCMA targeted CAR-NK cells injection

Intervention Type: DRUG

Allogenic genetically modified anti-BCMA CAR transduced NK cells

Interventions

Human BCMA targeted CAR-NK cells injection

Allogenic genetically modified anti-BCMA CAR transduced NK cells

Intervention Type: DRUG

Other Intervention Names

BCMA CAR-NK

Eligibility Criteria

Inclusion Criteria

• Subjects volunteer to participate in clinical trials, understand and sign the informed consent document, be willing to complete all the trial procedures;
• 18 years and older, Male and female;
• Expected survival > 12 weeks;
• Documented evidence of multiple myeloma at diagnosis as defined by IMWG updated criteria (2014), or plasma cell leukemia at diagnosis as defined by Diagnosis and therapeutic criteria of hematologic disease (4th edition);
• One of the following indicators is satisfied:

1. Serum M protein: IgG M protein ≥5 g/L; or IgA M protein ≥5 g/L; or IgD M protein and IgD >ULN;

2. Urine M protein ≥200 mg/24h;

3. Affected serum free light chain ≥100 mg/L and Serum free light chain ratio is abnormal;

4. Clonal bone marrow plasma cells ≥10 % for non-secretory myeloma;

• Patients with relapsed/refractory multiple myeloma or plasma cell leukemia, satisfying:

1. Patients have received at least 3 prior MM or PCL treatment regimens containing at least one proteasome inhibitor and one immunomodulatory;

2. Progress is documented within 60 days of the most recent anti-tumor treatment, or efficacy assessment does not reach minimal response(MR) or above;

• Liver, kidney and cardiopulmonary functions meet the following requirements:

1. Creatinine clearance rate (estimated by CockcroftGault formula) ≥30mL/min;

2. Left ventricular ejection fraction > 50%;

3. Baseline peripheral oxygen saturation > 95%;

4. Total bilirubin≤ 2×ULN; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5×ULN;

• Blood routine examination satisfying hemoglobin≥60 g/L, neutrophils≥ 1.0×10^9/L, and platelets≥30×10^9/L, can complete this trial according to the judgement of investigators.

Exclusion Criteria

• Accompanied by other uncontrolled malignancies;
• Subjects with positive Hepatitis B surface antigen(HBsAg) or Hepatitis B core antibody (HBcAb) and hepatitis B virus (HBV) DNA titers higher than the lower limit of the normal range of the investigative site; Hepatitis C virus (HCV) antibody positive and peripheral blood HCV RNA positive; Human Immunodeficiency Viral (HIV) antibody positive; syphilis primary screening antibody positive;
• Any instability of systemic disease, including but not limited to unstable angina, cerebrovascular accident, or transient cerebral ischemic (within 6 months prior to screening), myocardial infarction (within 6 months prior to screening), congestive heart failure (New York heart association (NYHA) classification ≥ III), need drug therapy of severe arrhythmia, liver, kidney, or metabolic disease;
• Subjects who are considered unsuitable to participate in this trial by the investigator.
• Pregnant or lactating woman, and female subject who plans to have a pregnancy within 1 year after cell transfusion, or male subject whose partner plans to have a pregnancy within 1 year after cell transfusion;
• Received CAR-NK treatment or other gene therapies before enrollment;
• Subjects who have a disease that affects the signing of written informed consent or who are unable to comply with research procedures; or who are unwilling or unable to comply with research requirements;
• Subjects who have had severe immediate hypersensitivity reactions to any drugs used in this research;
• Active or uncontrollable infection requiring systemic therapy within 14 days prior to enrollment;
• In the past two years, the terminal organ was damaged due to autoimmune diseases (such as Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus), or the systemic use of immunosuppressive or other systemic disease control drugs was required;
• Patients with symptoms of central nervous system.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Changzheng Hospital

OTHER

Sponsor Role: collaborator

Hrain Biotechnology Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Juan Du, Doctor

Role: PRINCIPAL_INVESTIGATOR

Shanghai Changzheng Hospital

Locations

Shanghai Changzheng Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xuedong Sun, Doctor

Role: CONTACT

sunxuedong@dashengbio.com

+8615811287219

Facility Contacts

Juan Du, Doctor

Role: primary

juan_du@live.com

0086-021-81885423

Other Identifiers

HRAIN01-MM04-POC

Identifier Type: -

Identifier Source: org_study_id