Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-01

Study Completion Date

2023-08-24

Brief Summary

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To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.

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Detailed Description

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Conditions

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Oral Lichen Planus Vitamin D Deficiency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Group A

35 OLP patients

ELISA

Intervention Type DEVICE

Enzyme-linked immunosorbent assay (ELISA) was used following manufacturer's instructions. This test uses a competitive ELISA-based technique that was designed to quantitatively determine the concentration of 1,25-dihydroxyvitamin D3/D2 in human serum.

Group B

35 healthy controls.

ELISA

Intervention Type DEVICE

Enzyme-linked immunosorbent assay (ELISA) was used following manufacturer's instructions. This test uses a competitive ELISA-based technique that was designed to quantitatively determine the concentration of 1,25-dihydroxyvitamin D3/D2 in human serum.

Interventions

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ELISA

Enzyme-linked immunosorbent assay (ELISA) was used following manufacturer's instructions. This test uses a competitive ELISA-based technique that was designed to quantitatively determine the concentration of 1,25-dihydroxyvitamin D3/D2 in human serum.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* (Group A) patients presenting with a clinical picture and histological findings that confirm the diagnosis of OLP
* (Group B) age, sex, and dietary habits matched healthy controls.

Exclusion Criteria

* (1) subjects who have been receiving any kind of VD supplements, multivitamins, or any drug that may affect VD measurements
* (2) patients with suspected restoration-related or smokeless tobacco-related lesions.
* (3) patients with any systemic medical condition or pregnant females.
* (4) patients with VD toxicity (VD≥100 ng/ml).

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes