Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure
NCT ID: NCT06020742
Last Updated: 2023-09-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2023-02-09
2024-12-31
Brief Summary
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(1）test the effectiveness and safety of automitochondrial transplantation of urine derived stem cells (2) establish intracytoplasmic sperm injection(ICSI) mitochondrial transplantation platform Participants will be asked to:1)urine collections to further culture of autologous USCs 2)ovarian stimulation、trigger eggs、ICSI with autologous mitochondria 3）embryo transfer 4)accept pregnancy follow-up at given point
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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MT transfer
Autologous USC mitochondrial oocyte transplantation
Mitochondria are isolated from urine derived stem cells from fresh middle urine of the subjects, and injected into the cytoplasm of mature oocytes together with sperm
Interventions
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Autologous USC mitochondrial oocyte transplantation
Mitochondria are isolated from urine derived stem cells from fresh middle urine of the subjects, and injected into the cytoplasm of mature oocytes together with sperm
Eligibility Criteria
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Inclusion Criteria
2. 2\) Repeated IVF failure: more than or equal to 2 egg retrieval with poor embryo quality, no transplanted embryos or failed embryo transfer (more than or equal to 4 embryos)
3. 3\) Egg number ≤9
4. 4\) Participate voluntarily and sign informed consent.
Exclusion Criteria
35 Years
FEMALE
No
Sponsors
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Peking University People's Hospital
OTHER
Responsible Party
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Han Hongjing
chief physician
Locations
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Peking University People's hospital
Beijing, Beijing Municipality, China
Countries
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Other Identifiers
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RDL2022-25
Identifier Type: -
Identifier Source: org_study_id
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