Interobserver Variability Desmoplasia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-01

Study Completion Date

2024-06-01

Brief Summary

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According to the most recent guideline of the National Comprehensive Cancer Network (NCCN), desmoplasia is considered to be a very high risk factor for recurrence, metastasis and death in cutaneous squamous cell carcinoma (cSCC). The presence of desmoplasia is assessed by dermatopathologists during histological examination of cSCCs. However, the inter-observer agreement is between dermatopathologists in the assessment of desmoplasia is unclear. Studies on inter-observer variability in the assessment of differentiation grade in cSCCs showed that there is only a weak to moderate agreement among dermatopathologists in the assessment of differentiation grade (2-4). This study aims to investigate the interobserver agreement of desmoplasia between dermatopathologists. In this prospective study, 50 cSCCs will be assessed for desmoplasia by at least eight dermatopathologists using a predefined definition.

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Detailed Description

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Conditions

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Cutaneous Squamous Cell Carcinoma Pathology Recurrence Metastasis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Presence of desmoplasia

Tumors with presence of desmoplasia according to the predefined definition.

Assessment by dermatopathologists

Intervention Type OTHER

Histological assessment of the cSCCs by eight dermatopathologists.

Absence of desmoplasia

Tumors in absence of desmoplasia according to the predefined definition.

Assessment by dermatopathologists

Intervention Type OTHER

Histological assessment of the cSCCs by eight dermatopathologists.

Interventions

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Assessment by dermatopathologists

Histological assessment of the cSCCs by eight dermatopathologists.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Histological coupes of patients with a cSCC between 2010 and 2018 (both cSCC with and without desmoplasia are included)
* Treated at the Maastricht University Medical Center+ (MUMC+)in Maastricht for their cSCC
* Of which the histology is available in the MUMC+