Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
115 participants
OBSERVATIONAL
2008-05-31
2009-05-31
Brief Summary
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Mohs micrographic surgery, the treatment of choice for higher risk BCC, allows for removal of lesions with preservation of healthy tissue. Although the BCC recurrence rate post Mohs surgery is estimated at 1-2%, recent data is lacking to validate this historical measurement.
Our purpose is to determine the current recurrence rate of BCC after Mohs surgery.
Detailed Description
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The Mohs surgery technique is associated with a low recurrence rate for BCC and is preferred for higher risk tumors and for tumors in cosmetically sensitive sites on the head and neck. While recurrence rates of BCC post Mohs are 1-2% for primary basal cells, recent data is not available to validate this historical assessment. Currently, comprehensive rates of recurrence are not available because a national registry of recurrence rates for BCC and squamous cell carcinoma (SCC) does not exist.
The purpose of this study is to both historically and prospectively assess current basal cell carcinoma recurrence rates in patients undergoing Mohs micrographic surgery.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Historical Arm
266 cases of BCC treated with Mohs surgery approximately 2-5 years ago will be assessed for recurrence.
No interventions assigned to this group
Prospective Arm
300 cases of BCC will be followed annually for 3 years after Mohs surgery to assess for recurrence.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Subjects who have undergone Mohs micrographic surgery for BCC on or before December 31, 2006
* Subjects with a medical record at the respective site
* Subjects in a stable health condition, as determined by the principle investigator
Exclusion Criteria
* Subjects with lesions only in areas other than the head, neck, genitalia,
* hands and feet
* Subjects who have not followed up through the Department of Dermatology
* Subjects with recurrent BCC lesions diagnosed on or prior to the recorded date of Mohs surgery
18 Years
ALL
No
Sponsors
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Northwestern University
OTHER
Responsible Party
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Murad Alam
Professor in Dermatology, Otolaryngology- Head and Neck Surgery, and Surgery-Organ Transplantation
Principal Investigators
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Murad Alam, MD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University
Locations
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Northwestern University Feinberg School of Medicine, Department of Dermatology
Chicago, Illinois, United States
DuPage Medical Group Dermatology
Naperville, Illinois, United States
Countries
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References
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Mehrany K, Weenig RH, Pittelkow MR, Roenigk RK, Otley CC. High recurrence rates of Basal cell carcinoma after mohs surgery in patients with chronic lymphocytic leukemia. Arch Dermatol. 2004 Aug;140(8):985-8. doi: 10.1001/archderm.140.8.985.
Robinson JK, Fisher SG. Recurrent basal cell carcinoma after incomplete resection. Arch Dermatol. 2000 Nov;136(11):1318-24. doi: 10.1001/archderm.136.11.1318.
Dubin N, Kopf AW. Multivariate risk score for recurrence of cutaneous basal cell carcinomas. Arch Dermatol. 1983 May;119(5):373-7.
Other Identifiers
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STU2538
Identifier Type: -
Identifier Source: org_study_id