A Prospective Cohort Study of Myasthenia Gravis in China

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

202 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-20

Study Completion Date

2026-09-30

Brief Summary

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The goal of this prospective cohort study is to investigate long-term therapeutic strategies for myasthenia gravis (MG) and identify potential biomarkers. The main questions it aims to answer are:

1. Whether low-dose oral steroids may lead to a reduction in the recurrence rate among patients with MG.
2. To identify potential biomarkers that can predict disease progression and prognosis.

This study recruits well-controlled patients with MG. Based on patient preferences and considerations such as coexisting conditions (e.g., uncontrolled hypertension, diabetes, severe osteoporosis, obesity), the participants will be non-randomly divided into two groups: a maintenance steroid therapy group and a withdrawal group (withdraw all immunosuppresants). Subsequently, these groups of patients will undergo long-term follow-up assessments.

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Detailed Description

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Conditions

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Myasthenia Gravis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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maintenance steroid therapy group

Maintaining low-dose oral steroids

Steroid Drug

Intervention Type DRUG

Maintaining low-dose oral steroids

immunosuppresants withdrawal group

Withdraw all immunosuppresants

Intervention Type OTHER

Withdraw all immunosuppresants

Interventions

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Steroid Drug

Maintaining low-dose oral steroids

Intervention Type DRUG

Withdraw all immunosuppresants

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 1: Attended the outpatient department of neurology of PUMCH from 9/30/2022 to 9/30/2024.
* 2: Diagnosed as myasthenia gravis.
* 3: Follow-up time at PUMCH\>6 months.
* 4: The patient understood and signed the informed consent form.

Exclusion Criteria

* 1: Comorbidities with other conditions that cause skeletal muscle weakness make the clinical symptoms difficult to assess
* 2: Records related to comorbidities and medications were not available at baseline and during follow-up.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No