Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

NCT ID: NCT05998473

Last Updated: 2023-08-21

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-06-01
• Study Completion Date: 2023-12-31

Brief Summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Detailed Description

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Conditions

Hydrocephalus; Parkinson Disease; Walking, Difficulty; Movement Disorders; Gait Ataxia; Diagnoses Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Normal pressure hydrocephalus

Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories

Dynamic stability measurement

Intervention Type: DIAGNOSTIC_TEST

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Parkinson's disease

Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories

Dynamic stability measurement

Intervention Type: DIAGNOSTIC_TEST

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Interventions

Dynamic stability measurement

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Age >18 years
• Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement
• Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion Criteria

• Levodopa drugs administrated during a delay of 12 hours before walking test
• Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Henri Mondor University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Emilie Hutin

Co-director of laboratory

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Emilie Hutin

Role: PRINCIPAL_INVESTIGATOR

Henri Mondor University Hospital

Locations

Laboratoire Analyse et Restauration du Mouvement

Créteil, , France

Countries

France

Other Identifiers

2023-A01762-43

Identifier Type: -

Identifier Source: org_study_id