PheCheck Feasibility Study

NCT ID: NCT05998109

Last Updated: 2025-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-15

Study Completion Date

2024-07-31

Brief Summary

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The goal of this feasibility study clinical trial is to compare the accuracy of PheCheck™ for the rapid quantitative detection of phenylalanine (Phe) with the gold standard (HPLC amino acid analyzer), in patients with PKU.

The main aims are:

* Evaluate the accuracy of PheCheck as compared to the gold standard
* Evaluate ease of use by lay participants

Detailed Description

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The primary objective of this feasibility study is to evaluate the accuracy of the analyte concentration of PheCheck™ for the rapid, quantitative detection of phenylalanine (Phe) from capillary blood compared to the gold standard (HPLC amino acid analyzer) which quantitatively measures Phe in venous blood.

The study will enroll subjects into one study cohort. It will include patients 10 years or older, monitored for Phenylketonuria (PKU), hyperphenylalaninemia or PKU during pregnancy.

Conditions

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Phenylketonurias

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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PheCheck™

Quantitative, single-use, rapid test Intended for home-based self-testing and monitoring of PKU.

1 fingerstick specimen collected at each study visit

Intervention Type DEVICE

HPLC Amino Acid Analyzer

1 venous specimen collected at each study visit

Intervention Type DIAGNOSTIC_TEST

Dried Blood Spot Cards

capillary blood specimen collected at each study visit

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 10 years of age or older
* Being monitored for Phenylketonuria (PKU), hyperphenylalaninemia or for PKU during pregnancy Signed informed consent

Exclusion Criteria

* Younger than 10 years of age
* Not being monitored for Phenylketonuria (PKU), hyperphenylalaninemia or for PKU during pregnancy
* Lack of signed informed consent
* Previous enrollment in the study and has completed study visit 1 and 2
Minimum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aptatek Biosciences

UNKNOWN

Sponsor Role collaborator

Lumos Diagnostics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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CLP-0012

Identifier Type: -

Identifier Source: org_study_id

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