A Prospective Clinical Study of Phenylketonuria (PKU)

NCT ID: NCT04452513

Last Updated: 2023-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

32 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-11

Study Completion Date

2022-06-02

Brief Summary

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This is a study for adults and children ≥ 14 years old who have Phenylketonuria (PKU) with uncontrolled plasma Phe levels. No clinical intervention or study drug is provided by BioMarin in this study.

Detailed Description

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Conditions

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Phenylketonurias

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Male and female subjects with diagnosis of PKU which is a condition characterized by PAH deficiency
* Ability and willingness to maintain dietary protein intake consistent with baseline intake
* Willingness and capable per investigator opinion to comply with study procedures and requirements
* Plasma Phe Levels \> 600umol/L

Exclusion Criteria

* Clinically significant liver dysfunction or disease
* Prior treatment with gene therapy
* Any condition that, in the opinion of the investigator or Sponsor, would prevent the subject from fully complying with the requirements of the study
Minimum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BioMarin Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Children's Hosptial of Colorado

Aurora, Colorado, United States

Site Status

University of Florida

Gainesville, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Emory University Hospital

Atlanta, Georgia, United States

Site Status

Ann & Robert H. Lurie Chilren's Hospital

Chicago, Illinois, United States

Site Status

Riley Hospital for Children

Indianapolis, Indiana, United States

Site Status

University of Kentucky

Lexington, Kentucky, United States

Site Status

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status

Morristown Medical Center

Morristown, New Jersey, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Clinic for Special Children

Strasburg, Pennsylvania, United States

Site Status

University of Texas Health Science Center at Houston

Houston, Texas, United States

Site Status

Medical College of Wisconsin

Wauwatosa, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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307-902

Identifier Type: -

Identifier Source: org_study_id

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