Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2018-06-12
2025-04-01
Brief Summary
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Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men. The investigators will isolate and expand spermatogonial cells from KS patients, then using an organoid model investigators will compare the behavior of these Spermatogonia from KS patients when interacting with four combinations of somatic cell types incorporated in the Extra Cellular Matrix hydrogel.
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Detailed Description
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One extra testicular biopsy (1-2 mm) will be cryopreserved and used later for the cells isolation and culture.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Infertile patients
Infertile patients going to surgery for fertility preservation or infertility treatment at University Clinic Saint-Luc Brussels
Testicular biopsy
Testicular biopsy is a clinical procedure for extraction of testicular tissue
Interventions
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Testicular biopsy
Testicular biopsy is a clinical procedure for extraction of testicular tissue
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
5 Years
50 Years
MALE
No
Sponsors
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Responsible Party
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Principal Investigators
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Christine Wyns, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Cliniques Universitaires St Luc
Locations
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Cliniques Universitaires St Luc
Brussels, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Christine Wyns, MD,PhD
Role: primary
References
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Giudice MG, Kanbar M, Poels J, Duquenne A, Wyns C. Long-term culture of human Sertoli cells from adult Klinefelter patients as a first step to develop new tools for unravelling the testicular physiopathology. Hum Reprod. 2024 Nov 1;39(11):2400-2410. doi: 10.1093/humrep/deae201.
Other Identifiers
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2018/27AVR/196
Identifier Type: -
Identifier Source: org_study_id
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