The Regulatory Role of Immune Response in Oral Lichen Planus

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-07

Study Completion Date

2025-02-28

Brief Summary

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Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it. In vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (MSCs) can secrete Ido, which is involved in the pathogenesis of OLP. It has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of OLP. Mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of OLP. In this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional Chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of OLP patients, so as to improve the therapeutic effect of OLP.

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Detailed Description

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Conditions

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Oral Lichen Planus

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Control

Normal control group

Control

Intervention Type OTHER

Investigation of scale of control

Non erosive OLP

Non erosive oral lichen planus

Non erosive OLP

Intervention Type OTHER

Investigation of cale of non erosive OLP patients

Erosive OLP

Erosive oral lichen planus

Erosive OLP

Intervention Type OTHER

Investigation of cale of erosive OLP patients

Interventions

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Non erosive OLP

Investigation of cale of non erosive OLP patients

Intervention Type OTHER

Erosive OLP

Investigation of cale of erosive OLP patients

Intervention Type OTHER

Control

Investigation of scale of control

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients with oral lichen planus
* male or female patients older than 18 years of age
* patients willing to participate with signed informed consent.

Exclusion Criteria

* pregnant or lactating
* had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors
* were unwilling to participate in the experiment.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes